Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 82: 1889-1896, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peters, J. K.
Right arrow Articles by Mack, G. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peters, J. K.
Right arrow Articles by Mack, G. W.

Journal of Applied Physiology
Vol. 82, No. 6, pp. 1889-1896, June 1997
SYSTEMIC CIRCULATION AND FLUID BALANCE

Venous and arterial reflex responses to positive-pressure breathing and lower body negative pressure

Jochen K. Peters, George Lister, Ethan R. Nadel, and Gary W. Mack

John B. Pierce Laboratory and Departments of Pediatrics, Epidemiology and Public Health, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519

Received 11 October 1996; accepted in final form 12 February 1997.

Peters, Jochen K., George Lister, Ethan R. Nadel, and Gary W. Mack. Venous and arterial reflex responses to positive-pressure breathing and lower body negative pressure. J. Appl. Physiol. 82(6): 1889-1896, 1997.---We examined the relative importance of arteriolar and venous reflex responses during reductions in cardiac output provoked by conditions that increase [positive end-expiratory pressure (PEEP)] or decrease [lower body negative pressure (LBNP)] peripheral venous filling. Five healthy subjects were exposed to PEEP (10, 15, 20, and 25 cmH2O) and LBNP (-10, -15, -20, and -25 mmHg) to induce progressive but comparable reductions in right atrial transmural pressure (control to minimum): from 5.9 ± 0.4 to 1.8 ± 0.7 and from 6.5 ± 0.6 to 2.0 ± 0.2 mmHg with PEEP and LBNP, respectively. Cardiac output (impedance cardiography) fell less during PEEP than during LBNP (from 3.64 ± 0.21 to 2.81 ± 0.21 and from 3.39 ± 0.21 to 2.14 ± 0.24 l · min-1 · m-2 with PEEP and LBNP, respectively), and mean arterial pressure increased. We observed sustained increases in forearm vascular resistance (i.e., forearm blood flow by venous occlusion plethysmography) and systemic vascular resistance that were greater during LBNP: from 19.7 ± 2.91 to 27.97 ± 5.46 and from 20.56 ± 2.48 to 50.25 ± 5.86 mmHg · ml-1 · 100 ml tissue-1 · min (P < 0.05) during PEEP and LBNP, respectively. Venomotor responses (venous pressure in the hemodynamically isolated limb) were always transient, significant only with the greatest reduction in right atrial transmural pressure, and were similar for LBNP and PEEP. Thus arteriolar rather than venous responses are predominant in blood volume mobilization from skin and muscle, and venoconstriction is not intensified with venous engorgement during PEEP.

central venous pressure; venomotor; vasoconstriction; positive end-expiratory pressure

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Kitano, J. K. Shoemaker, M. Ichinose, H. Wada, and T. Nishiyasu
Comparison of cardiovascular responses between lower body negative pressure and head-up tilt
J Appl Physiol, June 1, 2005; 98(6): 2081 - 2086.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Aljuri, R. Marini, and R. J. Cohen
Test of dynamic closed-loop baroreflex and autoregulatory control of total peripheral resistance in intact and conscious sheep
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2274 - H2286.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Fietze, D. Romberg, M. Glos, S. Endres, H. Theres, C. Witt, and V. K. Somers
Effects of positive-pressure ventilation on the spontaneous baroreflex in healthy subjects
J Appl Physiol, March 1, 2004; 96(3): 1155 - 1160.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. L. Hijmering, E. S. G. Stroes, J. Olijhoek, B. A. Hutten, P. J. Blankestijn, and T. J. Rabelink
Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation
J. Am. Coll. Cardiol., February 20, 2002; 39(4): 683 - 688.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Wu and G. W. Mack
Effect of lymphatic outflow pressure on lymphatic albumin transport in humans
J Appl Physiol, September 1, 2001; 91(3): 1223 - 1228.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Nakajima, T. Mizobe, A. Takamata, and Y. Tanaka
Baroreflex modulation of peripheral vasoconstriction during progressive hypothermia in anesthetized humans
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1430 - R1436.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. W. Mack
Assessment of cutaneous blood flow by using topographical perfusion mapping techniques
J Appl Physiol, July 1, 1998; 85(1): 353 - 359.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online