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J Appl Physiol 82: 1882-1888, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 6, pp. 1882-1888, June 1997
METABOLISM

Effect of glucose supplement timing on protein metabolism after resistance training

B. D. Roy1, M. A. Tarnopolsky1,2, J. D. Macdougall1, J. Fowles1, and K. E. Yarasheski3

1 Department of Kinesiology and 2 Department of Neurology and Physical Medicine and Rehabilitation, McMaster University, Hamilton, Ontario, Canada L8S 4K1; and 3 Metabolism Division, Washington University School of Medicine, St. Louis, Missouri 63110

Received 16 September 1996; accepted in final form 10 February 1997.

Roy, B. D., M. A. Tarnopolsky, J. D. MacDougall, J. Fowles, and K. E. Yarasheski. Effect of glucose supplement timing on protein metabolism after resistance training. J. Appl. Physiol. 82(6): 1882-1888, 1997.---We determined the effect of the timing of glucose supplementation on fractional muscle protein synthetic rate (FSR), urinary urea excretion, and whole body and myofibrillar protein degradation after resistance exercise. Eight healthy men performed unilateral knee extensor exercise (8 sets/~10 repetitions/~85% of 1 single maximal repetition). They received a carbohydrate (CHO) supplement (1 g/kg) or placebo (Pl) immediately (t = 0 h) and 1 h (t = +1 h) postexercise. FSR was determined for exercised (Ex) and control (Con) limbs by incremental L-[1-13C]leucine enrichment into the vastus lateralis over ~10 h postexercise. Insulin was greater (P < 0.01) at 0.5, 0.75, 1.25, 1.5, 1.75, and 2 h, and glucose was greater (P < 0.05) at 0.5 and 0.75 h for CHO compared with Pl condition. FSR was 36.1% greater in the CHO/Ex leg than in the CHO/Con leg (P = not significant) and 6.3% greater in the Pl/Ex leg than in the Pl/Con leg (P = not significant). 3-Methylhistidine excretion was lower in the CHO (110.43 ± 3.62 µmol/g creatinine) than Pl condition (120.14 ± 5.82, P < 0.05) as was urinary urea nitrogen (8.60 ± 0.66 vs. 12.28 ± 1.84 g/g creatinine, P < 0.05). This suggests that CHO supplementation (1 g/kg) immediately and 1 h after resistance exercise can decrease myofibrillar protein breakdown and urinary urea excretion, resulting in a more positive body protein balance.

muscle protein synthesis; protein degradation; 3-methylhistidine; urea nitrogen; and insulin

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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