| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211
Received 28 August 1996; accepted in final form 3 February 1997.
McAllister, Richard M., Brian L. Reiter, John F. Amann, and
M. Harold Laughlin. Skeletal muscle biochemical adaptations to
exercise training in miniature swine. J. Appl.
Physiol. 82(6): 1862-1868, 1997.
The primary
purpose of this study was to test the hypothesis that endurance
exercise training induces increased oxidative capacity in porcine
skeletal muscle. To test this hypothesis, female miniature swine were
either trained by treadmill running 5 days/wk over 16-20 wk (Trn;
n = 35) or pen confined (Sed;
n = 33). Myocardial
hypertrophy, lower heart rates during submaximal stages of a maximal
treadmill running test, and increased running time to exhaustion during
that test were indicative of training efficacy. A variety of skeletal
muscles were sampled and subsequently assayed for the enzymes citrate
synthase (CS), 3-hydroxyacyl-CoA dehydrogenase, and lactate
dehydrogenase and for antioxidant enzymes. Fiber type composition of a
representative muscle was also determined histochemically. The largest
increase in CS activity (62%) was found in the gluteus maximus muscle
(Sed, 14.7 ± 1.1 µmol · min
1 · g1;
Trn, 23.9 ± 1.0; P < 0.0005).
Muscles exhibiting increased CS activity, however, were located
primarily in the forelimb; ankle and knee extensor and respiratory
muscles were unchanged with training. Only two muscles exhibited higher
3-hydroxyacyl-CoA dehydrogenase activity in Trn compared with Sed.
Lactate dehydrogenase activity was unchanged with training, as were
activities of antioxidant enzymes. Histochemical analysis of the
triceps brachii muscle (long head) revealed lower type IIB fiber
numbers in Trn (Sed, 42 ± 6%; Trn, 10 ± 4;
P < 0.01) and greater type IID/X
fiber numbers (Sed, 11 ± 2; Trn, 22 ± 3;
P < 0.025). These findings
indicate that porcine skeletal muscle adapts to endurance exercise
training in a manner similar to muscle of humans and other animal
models, with increased oxidative capacity. Specific
muscles exhibiting these adaptations, however, differ between the
miniature swine and other species.
citrate synthase; oxidative capacity; 
-oxidation; antioxidant
enzymes; fiber type composition
This article has been cited by other articles:
|
|
 |
|
  F. Gondret, P. Hernandez, H. Remignon, and S. Combes Skeletal muscle adaptations and biomechanical properties of tendons in response to jump exercise in rabbits J Anim Sci, February 1, 2009; 87(2): 544 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. McAllister, S. C. Newcomer, E. R. Pope, J. R. Turk, and M. H. Laughlin Effects of chronic nitric oxide synthase inhibition on responses to acute exercise in swine J Appl Physiol, January 1, 2008; 104(1): 186 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Stahly, N. H. Williams, T. R. Lutz, R. C. Ewan, and S. G. Swenson Dietary B vitamin needs of strains of pigs with high and moderate lean growth J Anim Sci, January 1, 2007; 85(1): 188 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Massett and B. C. Berk Strain-dependent differences in responses to exercise training in inbred and hybrid mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1006 - R1013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Clowes, F. X. Aherne, and V. E. Baracos Skeletal muscle protein mobilization during the progression of lactation Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E564 - E572. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
