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1 Department of Physiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515; and 2 Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295
Received 18 November 1996; accepted in final form 24 February 1997.
O'Hagan, Kathleen P., Susan M. Casey, and Philip S. Clifford. Muscle chemoreflex increases renal
sympathetic nerve activity during exercise. J. Appl.
Physiol. 82(6): 1818-1825, 1997.
Activation of
the muscle chemoreflex increases sympathetic drive to skeletal muscle
in humans. This study investigated whether activation of the muscle
chemoreflex augments the renal sympathetic nerve activity (RSNA)
response to dynamic exercise in rabbits. The muscle chemoreflex was
evoked by hindlimb ischemia during exercise on a motorized treadmill.
Seven New Zealand White rabbits performed a nonischemic control
protocol and a hindlimb ischemia protocol in which terminal aortic
blood flow (
ta) was reduced to 51 ± 2% of
preocclusion ta by partial aortic occlusion after 1.5 min of exercise. Mean arterial pressure (MAP), heart rate, RSNA and
ta increased in response to exercise and were
similar between trials during the first 1.5 min of exercise. In the
control trial, ta, MAP, and RSNA were stable at an
elevated level through an additional 3.5 min of exercise. Hindlimb
ischemia produced a potent pressor response that plateaued after 2.5 min (
+17 ± 4 mmHg, where designates change). RSNA began to
increase after 1.5 min of ischemic exercise and was significantly
elevated relative to preocclusion RSNA at 2.5 (+25 ± 9%) and
3.5 (+47 ± 12%) min of occlusion. These results suggest that
the muscle chemoreflex can augment sympathoexcitatory drive to the
kidney during dynamic exercise.
rabbit; blood pressure; exercise pressor reflex; metaboreflex; sympathetic nervous system
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