Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 82: 1765-1770, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 6, pp. 1765-1770, June 1997
EXERCISE AND MUSCLE

Fibrinolytic responses to acute physical activity in older hypertensive men

Christopher A. Desouza1, Donald R. Dengel2, Marc A. Rogers1, Kim Cox3, and Richard F. Macko2,3

1 Department of Kinesiology, University of Maryland, College Park 20742; and 2 Division of Gerontology, Department of Medicine, and 3 Department of Neurology, University of Maryland Medical School and Baltimore Veterans Affairs Medical Center, Geriatric, Research, Education, and Clinical Center, Baltimore, Maryland 21201

Received 3 September 1996; accepted in final form 28 January 1997.

DeSouza, Christopher A., Donald R. Dengel, Marc A. Rogers, Kim Cox, and Richard F. Macko. Fibrinolytic responses to acute physical activity in older hypertensive men. J. Appl. Physiol. 82(6): 1765-1770, 1997.---We tested the hypothesis that the fibrinolytic response to acute physical activity is impaired in sedentary older hypertensive men, which may contribute to the risk of exertion-triggered acute myocardial infarction in this population. Tissue-type plasminogen activator (t-PA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) antigen and activity were measured in 12 hypertensive (69 ± 1 yr) and 11 normotensive (64 ± 1 yr) men before and after an acute bout of submaximal exercise. Contrary to our hypothesis, there were no differences between the two groups in the fibrinolytic response to exercise. t-PA antigen and activity were significantly elevated in both the hypertensive (38 and 172%, respectively) and normotensive (45 and 130%, respectively) groups immediately after exercise but they returned to resting levels within 30 min. There was no change in PAI-1 antigen levels immediately after exercise in either group; however, PAI-1 antigen was significantly lower at 30 and 60 min postexercise in both the hypertensive (31 and 16%, respectively) and normotensive (35 and 20%, respectively) groups. PAI-1 activity was significantly lower immediately after exercise in both the hypertensive (25%) and normotensive (22%) groups and remained lower than preexercise levels at 30 min (23 and 26%, respectively) and 60 min (16 and 12%, respectively) postexercise in both groups. The results of this study demonstrate that the fibrinolytic response to an acute bout of moderate physical activity is not impaired in sedentary older hypertensive men.

fibrinolysis; exercise; tissue-type plasminogen activator; plasminogen activator inhibitor-1

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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