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J Appl Physiol 82: 1726-1733, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 6, pp. 1726-1733, June 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Changes in leg vein filling and emptying characteristics and leg volumes during long-term head-down bed rest

Francis Louisy, Philippe Schroiff, and Antonio Güell

Departement de Physiologie Gravitationnelle, Institut de Médecine Aérospatiale du Service de Santé des Armées, 91223 Brétigny sur Orge; and Centre National d'Etudes Spatiales, 31055 Toulouse, France

Received 20 November 1996; accepted in final form 3 January 1997.

Louisy, Francis, Philippe Schroiff, and Antonio Güell. Changes in leg vein filling and emptying characteristics and leg volumes during long-term head-down bed rest. J. Appl. Physiol. 82(6): 1726-1733, 1997.---Leg venous hemodynamics [venous distensibility index (VDI), arterial flow index (AFI), half-emptying time (T1/2)], and leg volumes (LV) were assessed by mercury strain-gauge plethysmography with venous occlusion and volometry, respectively, in seven men before, during, and after 42 days of 6° head-down bed rest. Results showed a high increase in VDI up to day 26 of bed rest (+50% vs. control at day 26, P < 0.05), which tended to subside thereafter (+20% increase vs. control value at day 41, P < 0.05). VDI changes were associated with parallel changes in T1/2 (+54% vs. control at day 26 of bed rest, P < 0.05, and +25% vs. control at day 41, P < 0.05) and with a decrease in AFI (-49% at day 41 vs. control, P < 0.05). LV continuously decreased throughout bed rest (-13% vs. control at day 41, P < 0.05) but was correlated with VDI only during the first month of bed rest. These results show that during long-term 6° head-down bed rest alterations of leg venous compliance are associated with impairment of venous emptying capacities and arterial flow. Changes in skeletal muscle mass and fluid shifts may account for venous changes during the first month of bed rest but, subsequently, other physiological factors, to be determined, may also be involved in leg venous hemodynamic alterations.

weightlessness; leg venous compliance; skeletal muscle mass

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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