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Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208-3107; and Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093-0412
Received 19 August 1996; accepted in final form 14 January 1997.
Liu, S. Q. Regression of hypoxic hypertension-induced
changes in the elastic laminae of rat pulmonary arteries.
J. Appl. Physiol. 82(5):
1677-1684, 1997.
The elastic laminae of the pulmonary arteries
(PAs) undergo a progressive structural change in hypoxic hypertension.
This study focused on the reversibility of altered PA elastic laminae
of the rat due to hypoxic hypertension. The structure and
cross-sectional area of the PA medial elastic laminae were examined by
using electron-microscopic and image-analytic approaches during
recovery from 12 h and 10 days of hypoxic hypertension. At 12 h of
hypoxic hypertension, the elastic laminae, which appeared homogeneous
in normal control animals, were reorganized into structures composed of
randomly oriented filaments, with an increase in the cross-sectional
area of 70%. At 10 days of hypoxic hypertension, the elastic laminae
appeared homogeneous in structure and normal in cross-sectional area
despite continuous exposure to hypoxia. During recovery from 12 h of
hypoxic hypertension, the medial elastic laminae regained their
homogeneous structure and normal cross-sectional area after
day 2. During recovery from 10 days of
hypoxic hypertension, the medial elastic laminae changed from homogeneous to filamentous structures, with a progressively altered cross-sectional area that increased by 89% from recovery
day 0 to day
10 and returned to the normal level on
day 30. These changes were associated
with alterations in the PA wall tensile stress. These results indicated
that structural changes in the PA elastic laminae were reversible and
that the regression process depended on the duration of exposure to
hypoxia, the state of the elastic laminae, and possibly the tensile
stress level in the PA wall.
mechanical stress; vascular remodeling; electron microscopy
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