Journal of Applied Physiology AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 82: 1668-1676, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Topulos, G. P.
Right arrow Articles by Butler, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Topulos, G. P.
Right arrow Articles by Butler, J. P.

Journal of Applied Physiology
Vol. 82, No. 5, pp. 1668-1676, May 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

Fractional changes in lung capillary blood volume and oxygen saturation during the cardiac cycle in rabbits

George P. Topulos1,2, Nina R. Lipsky1, John L. Lehr1, Rick A. Rogers1, and James P. Butler1

1 Physiology Program, Harvard School of Public Health, and 2 Department of Anesthesia, Brigham and Women's Hospital, Boston, Massachusetts 02115

Received 16 January 1996; accepted in final form 26 December 1996.

Topulos, George P., Nina R. Lipsky, John L. Lehr, Rick A. Rogers, and James P. Butler. Fractional changes in lung capillary blood volume and oxygen saturation during the cardiac cycle in rabbits. J. Appl. Physiol. 82(5): 1668-1676, 1997.---Changes in local pulmonary capillary blood volume (Vc) and oxygen saturation (S) have been difficult to measure in live animals. By utilizing the differences in absorption of light at two wavelengths (650 and 800 nm), we estimated the fractional change in Vc and S during the course of the cardiac cycle in eight anesthetized, ventilated rabbits at low and high lung volumes. Observations were made of the pattern of diffusely backscattered light, from an ~1-cm3 volume of lung illuminated with a point source placed on the pleural surface through a thoracotomy. At low lung volume, the fractional change in Vc was ~13%, the change in S was ~4.6%, and the mean S was close to 77%. The fluctuations in Vc and S lagged behind peak systemic blood pressure by about one-fifth and three-fifths of a cycle, respectively. At high lung volume, there were no important fluctuations in Vc or S, and the mean S was ~82%. These results are consistent with fluctuations in pulmonary capillary pressure and gas exchange over the cardiac cycle, and with decreasing capillary compliance with increasing lung volume.

gas exchange; microcirculation; diffuse light scattering

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
G. P. Topulos, R. E. Brown, and J. P. Butler
Increased surface tension decreases pulmonary capillary volume and compliance
J Appl Physiol, September 1, 2002; 93(3): 1023 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Franceschini, D. A. Boas, A. Zourabian, S. G. Diamond, S. Nadgir, D. W. Lin, J. B. Moore, and S. Fantini
Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects
J Appl Physiol, January 1, 2002; 92(1): 372 - 384.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. P. Topulos, R. E. Brown, and J. P. Butler
Influence of lung volume on pulmonary microvascular pressure-volume characteristics
J Appl Physiol, October 1, 2000; 89(4): 1591 - 1600.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online