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Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx 10461; and Division of Circulatory Physiology, Department of Medicine, Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, New York 10032
Received 28 October 1996; accepted in final form 3 January 1997.
Katz, Stuart D., Jeannette Yuen, Rachel Bijou, and Thierry
H. LeJemtel. Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure.
J. Appl. Physiol. 82(5):
1488-1492, 1997.
The effects of physical training on
endothelium-dependent vasodilation in skeletal muscle resistance vessels were investigated in patients with heart failure. Forearm blood
flows
(ml · min
1 · 100 ml1) in response to
brachial arterial administration of acetylcholine (5 × 105 and 5 × 104 M at 1 ml/min) and
nitroglycerin (5 × 106 and 5 × 105 M at 1 ml/min) were
determined by strain-gauge venous occlusion plethysmography before and
after 8 wk of daily handgrip exercise in 12 patients with chronic heart
failure. After 8 wk of daily handgrip exercise, the vasodilatory
responses to acetylcholine significantly increased from pretraining
values, i.e., 16.6 ± 2.0 vs. 8.6 ± 1.3 ml · min1 · 100 ml1
(P < 0.05) and 27.5 ± 1.5 vs. 14.6 ± 1.7 ml · min1 · 100 ml1
(P < 0.05), respect- ively,
whereas the vasodilatory responses to nitroglycerin did not
change. Handgrip exercise training appears to specifically
enhance endothelium-dependent vasodilation in the forearm skeletal
muscle circulation of patients with heart failure.
congestive; exercise; physical training; acetylcholine; endothelium-derived relaxing factor
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