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Institute for Child Health Research, Perth, Western Australia 6001, Australia; and Department of Medical Informatics and Engineering and Institute of Experimental Surgery, Albert Szent-Györgyi Medical University, H-6701 Szeged, Hungary
Received 16 August 1996; accepted in final form 15 January 1997.
Peták, Ferenc, Zoltán Hantos, Ágnes
Adamicza, Tibor Asztalos, and Peter D. Sly. Methacholine-induced
bronchoconstriction in rats: effects of intravenous vs. aerosol
delivery. J. Appl. Physiol. 82(5):
1479-1487, 1997.
To determine the predominant site of action of
methacholine (MCh) on lung mechanics, two groups of open-chest
Sprague-Dawley rats were studied. Five rats were measured during
intravenous infusion of MCh (iv group), with doubling of concentrations
from 1 to 16 µg · kg
1 · min1.
Seven rats were measured after aerosol administration of MCh with doses
doubled from 1 to 16 mg/ml (ae group). Pulmonary input impedance
(ZL) between 0.5 and 21 Hz was
determined by using a wave-tube technique. A model containing airway
resistance (Raw) and inertance (Iaw) and parenchymal damping (G) and
elastance (H) was fitted to the
ZL spectra. In the iv group, MCh
induced dose-dependent increases in Raw [peak response 270 ± 9 (SE) % of the control level; P < 0.05] and in G (340 ± 150%;
P < 0.05), with no increase in
Iaw (30 ± 59%) or
H (111 ± 9%). In the ae group, the
dose-dependent increases in Raw (191 ± 14%;
P < 0.05) and
G (385 ± 35%; P < 0.05) were associated with a significant increase in H (202 ± 8%; P < 0.05).
Measurements with different resident gases [air vs. neon-oxygen
mixture, as suggested (K. R. Lutchen, Z. Hantos, F. Peták,
Á. Adamicza, and B. Suki. J. Appl.
Physiol. 80: 1841-1849, 1996)] in the
control and constricted states in another group of rats suggested that
the entire increase seen in G during the iv
challenge was due to ventilation inhomogeneity, whereas the ae
challenge might also have involved real tissue contractions via
selective stimulation of the muscarinic receptors.
airway resistance; lung tissue resistance; forced oscillations
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