| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institute for Child Health Research, Perth, Western Australia 6001, Australia; and Department of Medical Informatics and Engineering and Institute of Experimental Surgery, Albert Szent-Györgyi Medical University, H-6701 Szeged, Hungary
Received 16 August 1996; accepted in final form 15 January 1997.
Peták, Ferenc, Zoltán Hantos, Ágnes
Adamicza, Tibor Asztalos, and Peter D. Sly. Methacholine-induced
bronchoconstriction in rats: effects of intravenous vs. aerosol
delivery. J. Appl. Physiol. 82(5):
1479-1487, 1997.
To determine the predominant site of action of
methacholine (MCh) on lung mechanics, two groups of open-chest
Sprague-Dawley rats were studied. Five rats were measured during
intravenous infusion of MCh (iv group), with doubling of concentrations
from 1 to 16 µg · kg
1 · min1.
Seven rats were measured after aerosol administration of MCh with doses
doubled from 1 to 16 mg/ml (ae group). Pulmonary input impedance
(ZL) between 0.5 and 21 Hz was
determined by using a wave-tube technique. A model containing airway
resistance (Raw) and inertance (Iaw) and parenchymal damping (G) and
elastance (H) was fitted to the
ZL spectra. In the iv group, MCh
induced dose-dependent increases in Raw [peak response 270 ± 9 (SE) % of the control level; P < 0.05] and in G (340 ± 150%;
P < 0.05), with no increase in
Iaw (30 ± 59%) or
H (111 ± 9%). In the ae group, the
dose-dependent increases in Raw (191 ± 14%;
P < 0.05) and
G (385 ± 35%; P < 0.05) were associated with a significant increase in H (202 ± 8%; P < 0.05).
Measurements with different resident gases [air vs. neon-oxygen
mixture, as suggested (K. R. Lutchen, Z. Hantos, F. Peták,
Á. Adamicza, and B. Suki. J. Appl.
Physiol. 80: 1841-1849, 1996)] in the
control and constricted states in another group of rats suggested that
the entire increase seen in G during the iv
challenge was due to ventilation inhomogeneity, whereas the ae
challenge might also have involved real tissue contractions via
selective stimulation of the muscarinic receptors.
airway resistance; lung tissue resistance; forced oscillations
This article has been cited by other articles:
|
|
 |
|
  F. Petak, T. Z. Janosi, C. Myers, F. Fontao, and W. Habre Impact of elevated pulmonary blood flow and capillary pressure on lung responsiveness J Appl Physiol, September 1, 2009; 107(3): 780 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. T. Bates, M. Rincon, and C. G. Irvin Animal models of asthma Am J Physiol Lung Cell Mol Physiol, September 1, 2009; 297(3): L401 - L410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bayat, S. Strengell, L. Porra, T. Z. Janosi, F. Petak, H. Suhonen, P. Suortti, Z. Hantos, A. R. A. Sovijarvi, and W. Habre Methacholine and Ovalbumin Challenges Assessed by Forced Oscillations and Synchrotron Lung Imaging Am. J. Respir. Crit. Care Med., August 15, 2009; 180(4): 296 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Petak, G. Albu, E. Lele, Z. Hantos, D. R. Morel, F. Fontao, and W. Habre Lung mechanical and vascular changes during positive- and negative-pressure lung inflations: importance of reference pressures in the pulmonary vasculature J Appl Physiol, March 1, 2009; 106(3): 935 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Janosi, F. Petak, F. Fontao, D. R. Morel, M. Beghetti, and W. Habre Differential roles of endothelin-1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in isolated rat lung Exp Physiol, November 1, 2008; 93(11): 1210 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Chew, J. A. Hirota, R. Ellis, J. Wattie, M. D. Inman, and L. J. Janssen Effects of allergen on airway narrowing dynamics as assessed by lung-slice technique Eur. Respir. J., March 1, 2008; 31(3): 532 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Bozanich, T. Z. Janosi, R. A. Collins, C. Thamrin, D. J. Turner, Z. Hantos, and P. D. Sly Methacholine responsiveness in mice from 2 to 8 wk of age J Appl Physiol, August 1, 2007; 103(2): 542 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Strickland, P. A. Stumbles, G. R. Zosky, L. S. Subrata, J. A. Thomas, D. J. Turner, P. D. Sly, and P. G. Holt Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells J. Exp. Med., November 27, 2006; 203(12): 2649 - 2660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. T. Bates, S. S. Wagers, R. J. Norton, L. M. Rinaldi, and C. G. Irvin Exaggerated airway narrowing in mice treated with intratracheal cationic protein J Appl Physiol, February 1, 2006; 100(2): 500 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thamrin, P. D. Sly, and Z. Hantos Broadband frequency dependence of respiratory impedance in rats J Appl Physiol, October 1, 2005; 99(4): 1364 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Petak, B. Babik, Z. Hantos, D. R. Morel, J.-C. Pache, C. Biton, B. Suki, and W. Habre Impact of microvascular circulation on peripheral lung stability Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L879 - L889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ito, E. P. Ingenito, S. P. Arold, H. Parameswaran, N. T. Tgavalekos, K. R. Lutchen, and B. Suki Tissue heterogeneity in the mouse lung: effects of elastase treatment J Appl Physiol, July 1, 2004; 97(1): 204 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wagers, L. K. A. Lundblad, M. Ekman, C. G. Irvin, and J. H. T. Bates The allergic mouse model of asthma: normal smooth muscle in an abnormal lung? J Appl Physiol, June 1, 2004; 96(6): 2019 - 2027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Schutz, F. Petak, C. Barazzone-Argiroffo, F. Fontao, and W. Habre Effects of volatile anaesthetic agents on enhanced airway tone in sensitized guinea pigs Br. J. Anaesth., February 1, 2004; 92(2): 254 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Hantos, R. A. Collins, D. J. Turner, T. Z. Janosi, and P. D. Sly Tracking of airway and tissue mechanics during TLC maneuvers in mice J Appl Physiol, October 1, 2003; 95(4): 1695 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Huh, D. H. Strickland, F. L. Jahnsen, D. J. Turner, J. A. Thomas, S. Napoli, I. Tobagus, P. A. Stumbles, P. D. Sly, and P. G. Holt Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma: DC Activation Occurs in the Airway Mucosa but Not in the Lung Parenchyma J. Exp. Med., July 7, 2003; 198(1): 19 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Babik, T. Asztalos, F. Petak, Z. I. Deak, and Z. Hantos Changes in Respiratory Mechanics During Cardiac Surgery Anesth. Analg., May 1, 2003; 96(5): 1280 - 1287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. T. Bates and C. G. Irvin Measuring lung function in mice: the phenotyping uncertainty principle J Appl Physiol, April 1, 2003; 94(4): 1297 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Sly, R. A. Collins, C. Thamrin, D. J. Turner, and Z. Hantos Volume dependence of airway and tissue impedances in mice J Appl Physiol, April 1, 2003; 94(4): 1460 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Tulic and Q. Hamid Contribution of the Distal Lung to the Pathologic and Physiologic Changes in Asthma: Potential Therapeutic Target Roger S. Mitchell Lecture Chest, March 1, 2003; 123 (2009): 348S - 355S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. J. Evans, R. A. Bond, D. B. Corry, and F. R. Shardonofsky Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma J Appl Physiol, January 1, 2003; 94(1): 245 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tomioka, J. H. T. Bates, and C. G. Irvin Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations J Appl Physiol, July 1, 2002; 93(1): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Petak, W. Habre, Z. Hantos, P. D. Sly, and D. R. Morel Effects of pulmonary vascular pressures and flow on airway and parenchymal mechanics in isolated rat lungs J Appl Physiol, January 1, 2002; 92(1): 169 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Pillow, T. R. Korfhagen, M. Ikegami, and P. D. Sly Overexpression of TGF-alpha increases lung tissue hysteresivity in transgenic mice J Appl Physiol, December 1, 2001; 91(6): 2730 - 2734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. HALL, Z. HANTOS, and P. D. SLY Altered Respiratory Tissue Mechanics in Asymptomatic Wheezy Infants Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1387 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Petak, W. Habre, Y. R. Donati, Z. Hantos, and C. Barazzone-Argiroffo Hyperoxia-induced changes in mouse lung mechanics: forced oscillations vs. barometric plethysmography J Appl Physiol, June 1, 2001; 90(6): 2221 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Adamicza, F. Petak, T. Asztalos, L. Tiszlavicz, M. Boros, and Z. Hantos Endothelin-1-induced airway and parenchymal mechanical responses in guinea-pigs: the roles of ETA and ETB receptors Eur. Respir. J., May 1, 2001; 17(5): 975 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G L Hall, Z Hantos, J H Wildhaber, F Peták, and P D Sly Methacholine responsiveness in infants assessed with low frequency forced oscillation and forced expiration techniques Thorax, January 1, 2001; 56(1): 42 - 47. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Tulic, P. G. Holt, and P. D. Sly Modification of the Inflammatory Response to Allergen Challenge after Exposure to Bacterial Lipopolysaccharide Am. J. Respir. Cell Mol. Biol., May 1, 2000; 22(5): 604 - 612. [Abstract] [Full Text]
|
|
|
|
|
|
M. V. Sanchez-Cifuentes, M. L. Rubio, M. Ortega, G. Peces-Barba, M. Paiva, S. Verbanck, and N. G. Mangado Lung function and ventilation inhomogeneity in rat lungs after allergen challenge J Appl Physiol, March 1, 2000; 88(3): 821 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Petak, J. L. Wale, and P. D. Sly Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats J Appl Physiol, October 1, 1999; 87(4): 1373 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J L Wale, F Peták, and P D Sly Muscarinic blockade of methacholine induced airway and parenchymal lung responses in anaesthetised rats Thorax, June 1, 1999; 54(6): 531 - 537. [Abstract] [Full Text]
|
|
|
|
|
|
F. Petak, G. L. Hall, and P. D. Sly Repeated measurements of airway and parenchymal mechanics in rats by using low-frequency oscillations J Appl Physiol, May 1, 1998; 84(5): 1680 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. HAYDEN, F. PETAK, Z. HANTOS, G. HALL, and P. D. SLY Using Low-frequency Oscillation to Detect Bronchodilator Responsiveness in Infants Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 574 - 579. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
