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Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211
Received 15 August 1996; accepted in final form 30 December 1996.
McAllister, Richard M., and M. Harold Laughlin.
Short-term exercise training alters responses of porcine femoral
and brachial arteries. J. Appl.
Physiol. 82(5): 1438-1444, 1997.
The primary
purpose of this study was to test the hypothesis that short-term
exercise training enhances endothelium-dependent relaxation of porcine
femoral and brachial arteries. Miniature swine ran on a treadmill for 1 h at 3.5 miles/h, twice daily, for 7 consecutive days (Trn;
n = 8). Compared with sedentary
controls (Sed; n = 7), Trn swine
exhibited increased skeletal muscle citrate synthase activity
(P < 0.05). Vascular rings ~3 mm
in axial length were prepared from segments of femoral and brachial
arteries, and responses to vasoactive agents were determined in vitro.
Sensitivity to bradykinin (BK) was enhanced in brachial vascular rings
from Trn swine compared with those from Sed swine, as indicated by
lower concentration of vasorelaxing agent eliciting 50% of maximal
response values [Sed, 8.63 ± 0.09 (
log M); Trn, 9.07 ± 0.13; P < 0.05]. This
difference between groups was preserved in brachial rings in which
formation of nitric oxide and vasodilator prostaglandins were inhibited
[Sed, 8.57 ± 0.17 (log M); Trn, 8.97 ± 0.13;
P < 0.05]. Sensitivity to BK
was not different between Sed and Trn in femoral arterial rings.
Relaxation responses to the calcium ionophore A-23187 and sodium
nitroprusside were not altered with training. Femoral and brachial
arterial rings from Trn swine, compared with those from Sed swine,
exhibited augmented vasocontraction across a range of concentrations
and increased sensitivity to norepinephrine (all
P < 0.05). These findings indicate
that responses of porcine femoral and brachial arteries change in
response to short-term training. Together with findings from previous
studies involving longer term training, our data suggest that vascular adaptations may differ at different time points during long-term endurance exercise training.
norepinephrine; bradykinin; endothelium
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