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J Appl Physiol 82: 1378, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 4, pp. 1378-1378, April 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

SPECIAL COMMUNICATION

Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition

W. Michael Foster, Pamela T. Stetkiewicz, and Arthur N. Freed

Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205

Received 1 August 1996; accepted in final form 26 November 1996.

Foster, W. Michael, Pamela T. Stetkiewicz, and Arthur N. Freed. Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition. J. Appl. Physiol. 82(4): 1378-1382, 1997.---Clearance of low-molecular-weight solutes, e.g., radiolabeled chelate diethylenetriaminepentaacetate (DTPA), across epithelial surfaces of distal airways and the lung parenchyma is a broadly used technique to assess epithelial integrity. It has been generally assumed that clearance of solute follows a simple first-order process and that DTPA clearance through the respiratory epithelium and into blood and lymphatic channels is complete within a few hours. Using gamma -camera imaging and a radiolabeled aerosol of 99mTc-labeled DTPA, we observed in eight healthy subjects lung retention of radioisotope ~24 h postdeposition of the 99mTc-DTPA. Residual lung retention at the 24-h end point averaged 6.0 ± 1.8 (SD)% of the amount of radioisotope initially deposited in the lung. This suggests that for normal healthy subjects a small amount of the 99mTc radioisotope, either in a dissociated or chelated form, is nonpermeable or slowly cleared from respiratory tisssues.

respiratory epithelium; airway; ozone; technetium-99m-labeled diethylenetriaminepentaacetate

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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