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Exercise Physiology Laboratory, Departments of Human Biodynamics and Integrative Biology, University of California, Berkeley, California 94720
Received 3 September 1996; accepted in final form 15 November 1996.
Friedlander, Anne L., Gretchen A. Casazza, Michael A. Horning, Melvin J. Huie, and George A. Brooks. Training-induced alterations of glucose flux in men. J. Appl.
Physiol. 82(4): 1360-1369, 1997.
We examined the
hypothesis that glucose flux was directly related to relative exercise
intensity both before and after a 10-wk cycle ergometer training
program in 19 healthy male subjects. Two pretraining trials [45
and 65% of peak O2 consumption
(
O2 peak)] and
two posttraining trials (same absolute and relative intensities as 65%
pretraining) were performed for 90 min of rest and 1 h of cycling
exercise. After training, subjects increased
O2 peak by
9.4 ± 1.4%. Pretraining, the intensity effect on glucose kinetics was evident with rates of appearance
(Ra; 5.84 ± 0.23 vs. 4.73 ± 0.19 mg · kg
1 · min1),
disappearance (Rd; 5.78 ± 0.19 vs. 4.73 ± 0.19 mg · kg1 · min1),
oxidation (Rox; 5.36 ± 0.15 vs. 3.41 ± 0.23 mg · kg1 · min1),
and metabolic clearance (7.03 ± 0.56 vs. 5.20 ± 0.28 ml · kg1 · min1)
of glucose being significantly greater
(P 
0.05) in the 65% than the 45%
O2 peak trial. When
Rd was expressed as a percentage of total energy expended per minute
(Rd E), there was no
difference between the 45 and 65% intensities. Training did reduce
Ra (4.63 ± 0.25),
Rd (4.65 ± 0.24),
Rox (3.77 ± 0.43), and
Rd E (15.30 ± 0.40 to
12.85 ± 0.81) when subjects were tested at the same absolute workload (P 0.05). However, when
they were tested at the same relative workload,
Ra,
Rd, and
Rd E were not different,
although Rox was lower
posttraining (5.36 ± 0.15 vs. 4.41 ± 0.42, P 0.05). These results show
1) glucose use is directly related
to exercise intensity; 2) training
decreases glucose flux for a given power output;
3) when expressed as relative
exercise intensity, training does not affect the magnitude of blood
glucose use during exercise; 4)
training alters the pathways of glucose disposal.
stable isotopes; substrate selection; glucose recycling; relative vs. absolute intensity; exercise; crossover concept
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A. Coggan;, G. A. Brooks, and A. L. Friedlander Letters to the Editor J Appl Physiol, April 1, 1998; 84(4): 1480 - 1482. [Abstract] [Full Text] [PDF]
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