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Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215
Received 20 May 1996; accepted in final form 4 December 1996.
Suki, Béla, Huichin Yuan, Qin Zhang, and Kenneth R. Lutchen. Partitioning of lung tissue response and inhomogeneous airway constriction at the airway opening. J. Appl.
Physiol. 82(4): 1349-1359, 1997.
During a
bronchial challenge, much of the observed response of lung tissues is
an artifactual consequence of inhomogeneous airway constriction.
Inhomogeneities, in the sense of time constant inequalities, are an
inherently linear phenomenon. Conversely, if lung tissues respond to a
bronchoagonist, they become more nonlinear. On the basis of these
distinct responses, we present an approach to separate real tissue
changes from airway inhomogeneities. We developed a lung model that
includes airway inhomogeneities in the form of a continuous
distribution of airway resistances and nonlinear viscoelastic tissues.
Because time domain data are dominated by nonlinearities, whereas
frequency domain data are most sensitive to inhomogeneities, we apply a
combined time-frequency domain identification scheme. This model was
tested with simulated data from a morphometrically based airway model
mimicking gross peripheral airway inhomogeneities and shown capable of
recovering all tissue parameters to within 15% error. Application to
our previously measured data suggests that in dogs during histamine infusion 1) the distribution of
airway resistances increases widely and
2) lung tissues do respond but less
so than previously reported. This approach, then, is unique in its
ability to differentiate between airway and tissue responses to an
agonist from a single broadband measurement made at the airway opening.
lung resistance; lung elastance; tissue resistance nonlinearity; distribution of resistances; Wiener structure; Horsfield model
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