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Departments of Internal Medicine, Radiology, and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9034
Received 22 August 1996; accepted in final form 13 November 1996.
Takeda, S., E. Y. Wu, R. H. Epstein, A. S. Estrera, and C. C. W. Hsia. In vivo assessment of changes in air and tissue volumes after pneumonectomy. J. Appl.
Physiol. 82(4): 1340-1348, 1997.
We examined the
progression and topographical distribution of postpneumonectomy volume
changes in immature foxhounds undergoing right pneumonectomy (R-Pnx,
n = 5) or sham pneumonectomy (Sham, n = 6) at 2 mo of age and subsequently
raised to maturity. Volumes of lung air (Vair) and tissue
(Vti) were estimated by computerized tomography (CT) scan at 7, 22, and
52 wk after surgery at a transpulmonary pressure of 20 cmH2O. Estimates of Vti by CT scan
included both septal tissue as well as nonseptal tissue (small- and
medium-sized airways and blood vessels); these were compared with
estimates of septal Vti by an acetylene rebreathing (Rb) method. We
found significant correlations between these techniques
(VairCT = 0.83 VairRb + 275, R = 0.97;
VtiCT = 1.62 VtiRb 
30, R = 0.81). Extravascular septal Vti
returned to normal 7 wk after R-Pnx and remained normal up to maturity.
Nonseptal Vti remained significantly below normal. The greatest
increase in Vti occurred in the midlung region just cephalad and caudal
to the heart. After an early period of accelerated tissue growth after
R-Pnx, the rate of septal tissue growth matched that of somatic growth,
whereas nonseptal tissue growth lagged behind. Compensatory growth of
the remaining left lung was not associated with selective
alterations in thoracic development.
lung air volume; septal lung tissue volume; acetylene rebreathing technique; computerized tomographic scan; compensatory lung growth
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