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Department of Physiology, University of Kentucky, Lexington, Kentucky 40536
Received 2 May 1996; accepted in final form 18 November 1996.
Xu, Fadi, and Donald T. Frazier. Respiratory-related
neurons of the fastigial nucleus in response to chemical and mechanical challenges. J. Appl. Physiol. 82(4):
1177-1184, 1997.
Responses of cerebellar respiratory-related
neurons (CRRNs) within the rostral fastigial nucleus and the phrenic
neurogram to activation of respiratory mechano- and chemoreceptors were
recorded in anesthetized, paralyzed, and ventilated cats. Respiratory
challenges included the following: 1) cessation of the ventilator for a
single breath at the end of inspiration (lung inflation) or at
functional residual capacity, 2)
cessation of the ventilator for multiple breaths, and
3) exposure to hypercapnia. Nineteen
CRRNs having spontaneous activity during control conditions were
characterized as either independent (basic, n = 14) or dependent (pump,
n = 5) on the ventilator movement. Thirteen recruited CRRNs showed no respiratory-related activity until
breathing was stressed. Burst durations of expiratory CRRNs were
prolonged by sustained lung inflation but were inhibited when the
volume was sustained at functional residual capacity; it was vice versa
for inspiratory CRRNs. Multiple-breath cessation of the ventilator and
hypercapnia significantly increased the firing rate and/or
burst duration concomitant with changes noted in the phrenic neurogram.
We conclude that CRRNs respond to respiratory inputs from
CO2 chemo- and pulmonary
mechanoreceptors in the absence of skeletal muscle contraction.
respiratory control; cerebellum; hypercapnia; lung inflation; movement of skeletal muscles
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