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J Appl Physiol 82: 1112-1118, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 4, pp. 1112-1118, April 1997
EXERCISE AND MUSCLE

Effects of nandrolone decanoate on respiratory and peripheral muscles in male and female rats

Anja Bisschop1, Ghislaine Gayan-Ramirez2, Hélène Rollier2, P. N. Richard Dekhuijzen2, René Dom3, Vera De Bock2, and Marc Decramer2

1 Faculty of Physical Education and Physiotherapy, 2 Respiratory Muscle Research Unit, Laboratory of Pneumology, and Respiratory Division, 3 Department of Neuropathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Received 7 June 1994; accepted in final form 12 November 1996.

Bisschop, Anja, Ghislaine Gayan-Ramirez, Hélène Rollier, P. N. Richard Dekhuijzen, René Dom, Vera de Bock, and Marc Decramer. Effects of nandrolone decanoate on respiratory and peripheral muscles in male and female rats. J. Appl. Physiol. 82(4): 1112-1118, 1997.---Thirty male and 18 female adult rats received weekly an intramuscular injection of either saline (control; C), 1.5 mg/kg (low-dose; LD) nandrolone decanoate or 7.5 mg/kg (high-dose; HD) nandrolone decanoate during 5 wk. Compared with respective C, growth rate was stunted in male HD rats from 2 wk of treatment on, whereas it was enhanced in female LD and HD rats after 1 wk. Mass of all muscles studied varied proportionally to body weight, except for the gastrocnemius (males: 0.49 ± 0.04 vs. C: 0.52 ± 0.03%, not significant; females: 0.17 ± 0.01 vs. C: 0.15 ± 0.01%, P < 0.05). In vitro contractile and fatigue properties of the diaphragm remained unchanged, except for a decrease in twitch kinetics (time to peak tension: C, 21 ± 2; LD, 19 ± 1; HD, 19 ± 2 ms, P < 0.05; half-relaxation time: C, 26 ± 5, LD, 25 ± 5, HD, 23 ± 3 ms, P < 0.01). Histochemistry of the diaphragm and the gastrocnemius revealed a significant increase in type IIx/b dimensions. In the gastrocnemius, type I fiber dimensions also increased. A pair-fed study, including another 24 female rats, showed that the changes in oral food intake only partly accounted for the observed anabolic effects.

anabolic steroids; contractile and fatigue properties; histochemistry; diaphragm; gender differences; adult rats; oral intake

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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