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1 Faculty of Physical Education
and Physiotherapy, 2 Respiratory
Muscle Research Unit,
Received 7 June 1994; accepted in final form 12 November 1996.
Bisschop, Anja, Ghislaine Gayan-Ramirez, Hélène
Rollier, P. N. Richard Dekhuijzen, René Dom, Vera de Bock, and
Marc Decramer. Effects of nandrolone decanoate on respiratory and peripheral muscles in male and female rats. J. Appl.
Physiol. 82(4): 1112-1118, 1997.
anabolic steroids; contractile and fatigue properties; histochemistry; diaphragm; gender differences; adult rats; oral intake
Thirty male
and 18 female adult rats received weekly an intramuscular injection of
either saline (control; C), 1.5 mg/kg (low-dose; LD) nandrolone
decanoate or 7.5 mg/kg (high-dose; HD) nandrolone decanoate during 5 wk. Compared with respective C, growth rate was stunted in male HD rats
from 2 wk of treatment on, whereas it was enhanced in female LD and HD
rats after 1 wk. Mass of all muscles studied varied proportionally to
body weight, except for the gastrocnemius (males: 0.49 ± 0.04 vs. C: 0.52 ± 0.03%, not significant; females: 0.17 ± 0.01 vs. C: 0.15 ± 0.01%, P < 0.05). In vitro contractile and
fatigue properties of the diaphragm remained unchanged, except for a
decrease in twitch kinetics (time to peak tension: C, 21 ± 2; LD,
19 ± 1; HD, 19 ± 2 ms, P < 0.05; half-relaxation time: C, 26 ± 5, LD, 25 ± 5, HD, 23 ± 3 ms, P < 0.01).
Histochemistry of the diaphragm and the gastrocnemius revealed a
significant increase in type IIx/b dimensions. In the gastrocnemius,
type I fiber dimensions also increased. A pair-fed study, including
another 24 female rats, showed that the changes in oral food intake
only partly accounted for the observed anabolic effects.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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