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1 Laboratoire de Physiologie,
Received 19 March 1996; accepted in final form 21 November 1996.
Vaïda, Pierre, Christian Kays, Daniel Rivière,
Pierre Téchoueyres, and Jean-Luc Lachaud.
Pulmonary diffusing capacity and pulmonary capillary blood volume
during parabolic flights. J. Appl.
Physiol. 82(4): 1091-1097, 1997.
capillary distension; gravitational physiology; lung function
Data from the
Spacelab Life Sciences-1 (SLS-1) mission have shown sustained but
moderate increase in pulmonary diffusing capacity
(DL). Because of the occupational constraints of the mission, data were only obtained after
24 h of exposure to microgravity. Parabolic flights are often used to
study some effects of microgravity, and we measured changes in
DL occurring at the very onset
of weightlessness. Measurements of
DL, membrane diffusing capacity,
and pulmonary capillary blood volume were made in 10 male subjects
during the 20-s 0-G phases of parabolic flights performed by the
"zero-G" Caravelle aircraft. Using the standardized single-breath
technique, we measured
DL for CO and
nitric oxide simultaneously. We found significant increases in
DL for CO (62%),
in membrane diffusing capacity for CO (47%), in
DL for nitric oxide (47%), and
in pulmonary capillary blood volume (71%). We conclude that major
changes in the alveolar membrane gas transfers and in the pulmonary
capillary bed occur at the very onset of microgravity. Because these
changes are much greater than those reported during sustained
microgravity, the effects of rapid transition from hypergravity to
microgravity during parabolic flights remain questionable.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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