Journal of Applied Physiology
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J Appl Physiol 82: 1084-1090, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 4, pp. 1084-1090, April 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

Hypoxic vasoconstriction in pulmonary arterioles and venules

Simon C. Hillier1, Jacquelyn A. Graham1, Christopher C. Hanger1, Patricia S. Godbey1, Robb W. Glenny4, and Wiltz W. Wagner Jr.1,2,3

1 Department of Anesthesia, 2 Department of Physiology/Biophysics, and 3 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202; and 4 Departments of Medicine and of Physiology and Biophysics, University of Washington, Seattle, Washington 98195

Received 22 February 1996; accepted in final form 15 November 1996.

Hillier, Simon C., Jacquelyn A. Graham, Christopher C. Hanger, Patricia S. Godbey, Robb W. Glenny, and Wiltz W. Wagner, Jr. Hypoxic vasoconstriction in pulmonary arterioles and venules. J. Appl. Physiol. 82(4): 1084-1090, 1997.---Pulmonary microvessels (<70 µm) lack a complete muscular media. We tested the hypothesis that these thin-walled vessels do not participate in the hypoxic pressor response. Isolated canine lobes were pump perfused at precisely known microvascular pressures. A videomicroscope, coupled to a computerized image-enhancement system, permitted accurate diameter measurements of subpleural arterioles and venules, with each vessel serving as its own control. While vascular pressure was maintained constant throughout the protocol, hypoxia caused an average reduction of 25% of microvessel diameters. The constriction was reversed when nitric oxide was added to the hypoxic gas mixture. The nitric oxide reversal, combined with a lack of lobar blood flow redistribution as measured by fluorescent microspheres, shows that the constriction was active. This response suggests the unexpected potential for active intra-acinar ventilation-perfusion matching.

pulmonary circulation; nitric oxide; pulmonary microcirculation; videomicroscopy; hypoxic pulmonary vasoconstriction; dogs

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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