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Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Departments of Atmospheric Sciences, Environmental Health, and Statistics, University of Washington, Seattle, Washington 98195-6522
Received 30 April 1996; accepted in final form 28 October 1996.
Robertson, H. Thomas, Robb W. Glenny, Derek Stanford, Lynn
M. McInnes, Daniel L. Luchtel, and David Covert. High-resolution maps of regional ventilation utilizing inhaled fluorescent
microspheres. J. Appl. Physiol. 82(3):
943-953, 1997.
The regional deposition of an inhaled aerosol of
1.0-µm diameter fluorescent microspheres (FMS) was used to produce
high-resolution maps of regional ventilation. Five anesthetized, prone,
mechanically ventilated pigs received two 10-min inhalations of pairs
of different FMS labels, accompanied by intravenous injection of
15.0-µm radioactive microspheres. The lungs were air dried and cut
into 1.9-cm3 pieces, with notation
of the spatial coordinates for each piece. After measurement of
radioactive energy peaks, the tissue samples were soaked in
2-ethoxyethyl acetate, and fluorescent emission peaks were recorded for
the wavelengths specific to each fluorescence label. The correlation of
fluorescence activity between simultaneously administered inhaled FMS
ranged from 0.98 to 0.99. The mean coefficient of variation for
ventilation for all 10 trials (47.9 ± 8.1%) was similar to that
for perfusion (46.2 ± 6.3%). No physiologically significant
gravitational gradient of ventilation or perfusion was present in the
prone animals. The strongest predictor of the magnitude of regional
ventilation among all animals was regional perfusion
(r = 0.77 ± 0.13).
pulmonary aerosol deposition; ventilation heterogeneity; ventilation-perfusion heterogeneity; gravitational gradient; radial gradient; pigs
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