| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Departments of Atmospheric Sciences, Environmental Health, and Statistics, University of Washington, Seattle, Washington 98195-6522
Received 30 April 1996; accepted in final form 28 October 1996.
Robertson, H. Thomas, Robb W. Glenny, Derek Stanford, Lynn
M. McInnes, Daniel L. Luchtel, and David Covert. High-resolution maps of regional ventilation utilizing inhaled fluorescent
microspheres. J. Appl. Physiol. 82(3):
943-953, 1997.
The regional deposition of an inhaled aerosol of
1.0-µm diameter fluorescent microspheres (FMS) was used to produce
high-resolution maps of regional ventilation. Five anesthetized, prone,
mechanically ventilated pigs received two 10-min inhalations of pairs
of different FMS labels, accompanied by intravenous injection of
15.0-µm radioactive microspheres. The lungs were air dried and cut
into 1.9-cm3 pieces, with notation
of the spatial coordinates for each piece. After measurement of
radioactive energy peaks, the tissue samples were soaked in
2-ethoxyethyl acetate, and fluorescent emission peaks were recorded for
the wavelengths specific to each fluorescence label. The correlation of
fluorescence activity between simultaneously administered inhaled FMS
ranged from 0.98 to 0.99. The mean coefficient of variation for
ventilation for all 10 trials (47.9 ± 8.1%) was similar to that
for perfusion (46.2 ± 6.3%). No physiologically significant
gravitational gradient of ventilation or perfusion was present in the
prone animals. The strongest predictor of the magnitude of regional
ventilation among all animals was regional perfusion
(r = 0.77 ± 0.13).
pulmonary aerosol deposition; ventilation heterogeneity; ventilation-perfusion heterogeneity; gravitational gradient; radial gradient; pigs
This article has been cited by other articles:
|
|
 |
|
  A. Kozian, T. Schilling, F. Freden, E. Maripuu, C. Rocken, C. Strang, T. Hachenberg, and G. Hedenstierna One-lung ventilation induces hyperperfusion and alveolar damage in the ventilated lung: an experimental study Br. J. Anaesth., April 1, 2008; 100(4): 549 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Robertson, B. Neradilek, N. L. Polissar, and R. W. Glenny Sporadic coordinated shifts of regional ventilation and perfusion in juvenile pigs with normal gas exchange J. Physiol., September 1, 2007; 583(2): 743 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chon, K. C. Beck, B. A. Simon, H. Shikata, O. I. Saba, and E. A. Hoffman Effect of low-xenon and krypton supplementation on signal/noise of regional CT-based ventilation measurements J Appl Physiol, April 1, 2007; 102(4): 1535 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Galvin, G. B. Drummond, and M. Nirmalan Distribution of blood flow and ventilation in the lung: gravity is not the only factor Br. J. Anaesth., April 1, 2007; 98(4): 420 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Robertson and M. P. Hlastala Microsphere maps of regional blood flow and regional ventilation J Appl Physiol, March 1, 2007; 102(3): 1265 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. C. Tsang, W. J. E. Lamm, B. Neradilek, N. L. Polissar, and M. P. Hlastala Endothelin receptor blockade does not improve hypoxemia following acute pulmonary thromboembolism J Appl Physiol, February 1, 2007; 102(2): 762 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Yun, P. Y. Lee, and A. N. Gerber Integrating systems biology and medical imaging: understanding disease distribution in the lung model. Am. J. Roentgenol., April 1, 2006; 186(4): 925 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Hoffman and D. Chon Computed Tomography Studies of Lung Ventilation and Perfusion Proceedings of the ATS, December 1, 2005; 2(6): 492 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. R. Starr, W. J. E. Lamm, B. Neradilek, N. Polissar, R. W. Glenny, and M. P. Hlastala Regional hypoxic pulmonary vasoconstriction in prone pigs J Appl Physiol, July 1, 2005; 99(1): 363 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mansson, A. J. Deninger, P. Magnusson, G. Pettersson, L. E. Olsson, G. Hansson, P. Wollmer, and K. Golman 3He MRI-based assessment of posture-dependent regional ventilation gradients in rats J Appl Physiol, June 1, 2005; 98(6): 2259 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Altemeier, S. McKinney, M. Krueger, and R. W. Glenny Effect of posture on regional gas exchange in pigs J Appl Physiol, December 1, 2004; 97(6): 2104 - 2111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Hlastala, W. J. E. Lamm, A. Karp, N. L. Polissar, I. R. Starr, and R. W. Glenny Spatial distribution of hypoxic pulmonary vasoconstriction in the supine pig J Appl Physiol, May 1, 2004; 96(5): 1589 - 1599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Porra, S. Monfraix, G. Berruyer, G. Le Duc, C. Nemoz, W. Thomlinson, P. Suortti, A. R. A. Sovijarvi, and S. Bayat Effect of tidal volume on distribution of ventilation assessed by synchrotron radiation CT in rabbit J Appl Physiol, May 1, 2004; 96(5): 1899 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Petersson, A. Sanchez-Crespo, M. Rohdin, S. Montmerle, S. Nyren, H. Jacobsson, S. A. Larsson, S. G. E. Lindahl, D. Linnarsson, R. W. Glenny, et al. Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion J Appl Physiol, March 1, 2004; 96(3): 1127 - 1136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chang, S. J. Lai-Fook, K. B. Domino, C. Schimmel, J. Hildebrandt, H. T. Robertson, R. W. Glenny, and M. P. Hlastala Spatial distribution of ventilation and perfusion in anesthetized dogs in lateral postures J Appl Physiol, February 1, 2002; 92(2): 745 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Kreck, M. A. Krueger, W. A. Altemeier, S. E. Sinclair, H. T. Robertson, E. D. Shade, J. Hildebrandt, W. J. E. Lamm, D. A. Frazer, N. L. Polissar, et al. Determination of regional ventilation and perfusion in the lung using xenon and computed tomography J Appl Physiol, October 1, 2001; 91(4): 1741 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Beck and T. A. Wilson Variance of ventilation during exercise J Appl Physiol, June 1, 2001; 90(6): 2151 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Gerbino, W. A. Altemeier, C. Schimmel, and R. W. Glenny Endotoxemia increases relative perfusion to dorsal-caudal lung regions J Appl Physiol, April 1, 2001; 90(4): 1508 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Marcucci, D. Nyhan, and B. A. Simon Distribution of pulmonary ventilation using Xe-enhanced computed tomography in prone and supine dogs J Appl Physiol, February 1, 2001; 90(2): 421 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, H. T. Robertson, and M. P. Hlastala Vasomotor tone does not affect perfusion heterogeneity and gas exchange in normal primate lungs during normoxia J Appl Physiol, December 1, 2000; 89(6): 2263 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, S. L. Bernard, and H. T. Robertson Pulmonary blood flow remains fractal down to the level of gas exchange J Appl Physiol, August 1, 2000; 89(2): 742 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Gerbino, S. McKinney, and R. W. Glenny Correlation between ventilation and perfusion determines VA/Q heterogeneity in endotoxemia J Appl Physiol, June 1, 2000; 88(6): 1933 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Altemeier, S. McKinney, and R. W. Glenny Fractal nature of regional ventilation distribution J Appl Physiol, May 1, 2000; 88(5): 1551 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mure, K. B. Domino, S. G. E. Lindahl, M. P. Hlastala, W. A. Altemeier, and R. W. Glenny Regional ventilation-perfusion distribution is more uniform in the prone position J Appl Physiol, March 1, 2000; 88(3): 1076 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. KOHLHÄUFL, P. BRAND, G. SCHEUCH, T. S. MEYER, H. SCHULZ, K. HÄUSSINGER, and J. HEYDER Increased Fine Particle Deposition in Women with Asymptomatic Nonspecific Airway Hyperresponsiveness Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 902 - 906. [Abstract] [Full Text]
|
|
|
|
|
|
W. A. Altemeier, H. T. Robertson, S. McKinney, and R. W. Glenny Pulmonary embolization causes hypoxemia by redistributing regional blood flow without changing ventilation J Appl Physiol, December 1, 1998; 85(6): 2337 - 2343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Altemeier, H. T. Robertson, and R. W. Glenny Pulmonary gas-exchange analysis by using simultaneous deposition of aerosolized and injected microspheres J Appl Physiol, December 1, 1998; 85(6): 2344 - 2351. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
