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J Appl Physiol 82: 933-942, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 3, pp. 933-942, March 1997
GAS EXCHANGE, MECHANICS, AND AIRWAYS

Shunt and ventilation-perfusion distribution during partial liquid ventilation in healthy piglets

Elisabeth A. Mates, Jacob Hildebrandt, J. Craig Jackson, Peter Tarczy-Hornoch, and Michael P. Hlastala

Departments of Physiology and Biophysics, Medicine, and Pediatrics, University of Washington, Seattle, Washington 98195-6522

Received 1 May 1996; accepted in final form 28 October 1996.

Mates, Elisabeth A., Jacob Hildebrandt, J. Craig Jackson, Peter Tarczy-Hornoch, and Michael P. Hlastala. Shunt and ventilation-perfusion distribution during partial liquid ventilation in healthy piglets. J. Appl. Physiol. 82(3): 933-942, 1997.---Replacing gas in the lung with perfluorocarbon fluids (PFC) and periodically ventilating with a gas [partial liquid ventilation (PLV)] has been shown to improve oxygenation in models of respiratory distress syndrome. We hypothesized that the addition of PFC to healthy lungs would result in shunt, diffusion impairment, and increased ventilation-perfusion (VA/Q) heterogeneity. Previously, Mates et al. showed that O2 shunt and arterial-alveolar CO2 difference increased linearly with dose in piglets given graded intratracheal doses of PFC (10, 20, and 30 ml/kg followed by mechanical ventilation with 100% O2) (E. A. Mates, J. C. Jackson, J. Hildebrandt, W. E. Truog, T. A. Standaert, and M. P. Hlastala. In: Oxygen Transport to Tissue XVI, 1994, p. 427-435). Here we report VA/Q distribution in the same animals, showing a 50% increase in VA/Q heterogeneity during PLV independent of PFC dose. Ventilation heterogeneity was the major factor in this increase, and there was no significant change in dead space ventilation. We also report on five animals given a single 20 ml/kg dose of PFC and followed for 3 h. They showed an increase in shunt during PLV but no change in arterial-alveolar CO2 difference.

perfluorochemical liquids; multiple inert gas elimination technique; gas exchange; ventilation-perfusion heterogeneity

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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