| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, Torrance, California 90509
Received 22 July 1996; accepted in final form 24 October 1996.
Stringer, William W., James E. Hansen, and K. Wasserman.
Cardiac output estimated noninvasively from oxygen uptake during
exercise. J. Appl. Physiol. 82(3):
908-912, 1997.
Because gas-exchange measurements during
cardiopulmonary exercise testing allow noninvasive measurement of
oxygen uptake (
O2), which
is equal to cardiac output (CO) × arteriovenous oxygen
content difference [C(a-vDO2)],
CO and stroke volume could theoretically be estimated if the
C(a-vDO2)
increased in a predictable fashion as a function of %maximum
O2
(O2 max) during
exercise. To investigate the behavior of
C(a-vDO2)
during progressively increasing ramp pattern cycle ergometry exercise,
5 healthy subjects performed 10 studies to exhaustion while arterial
and mixed venous blood were sampled. Samples were analyzed for
blood gases (pH, PCO2,
PO2) and oxyhemoglobin and hemoglobin
concentration with a CO-oximeter. The
C(a-vDO2)
(ml/100 ml) could be estimated with a linear regression [C(a-vDO2) = 5.72 + 0.105 × %O2 max;
r = 0.94]. The CO estimated from
the C(a-vDO2)
by using the above linear regression was well correlated with
the CO determined by the direct Fick method
(r = 0.96). The coefficient of
variation of the estimated CO was small (7-9%) between the lactic
acidosis threshold and peak
O2. The behavior
of C(a-vDO2),
as related to peak
O2, was similar regardless of cardiac function compared with similar measurements from
studies in the literature performed in normal and congestive heart
failure patients. In summary, CO and stroke volume can be estimated
during progressive work rate exercise testing from measured O2 (in normal subjects and
patients with congestive heart failure), and the resultant linear
regression equation provides a good estimate of
C(a-vDO2).
ramp pattern cycle ergometer exercise; arterial oxygen content; mixed venous oxygen content; direct Fick cardiac output
This article has been cited by other articles:
|
|
 |
|
  K. C. Peebles, A. M. Richards, L. Celi, K. McGrattan, C. J. Murrell, and P. N. Ainslie Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases J Appl Physiol, October 1, 2008; 105(4): 1060 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gonzalez-Alonso Point:Counterpoint: Stroke volume does/does not decline during exercise at maximal effort in healthy individuals J Appl Physiol, January 1, 2008; 104(1): 275 - 276. [Full Text] [PDF]
|
|
|
|
 |
|
 J A Laukkanen, S Kurl, J T Salonen, T A Lakka, and R Rauramaa Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death Heart, September 1, 2006; 92(9): 1219 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alonso-Fernandez, F. Garcia-Rio, and M. A. Arias Obstructive sleep apnoea-hypopnoea syndrome reversibly depresses cardiac response to exercise: reply Eur. Heart J., July 1, 2006; 27(13): 1633 - 1634. [Full Text] [PDF]
|
|
|
|
|
|
S. P. Dufour, E. Ponsot, J. Zoll, S. Doutreleau, E. Lonsdorfer-Wolf, B. Geny, E. Lampert, M. Fluck, H. Hoppeler, V. Billat, et al. Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity J Appl Physiol, April 1, 2006; 100(4): 1238 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Agostoni, G. Cattadori, A. Apostolo, M. Contini, P. Palermo, G. Marenzi, and K. Wasserman Noninvasive Measurement of Cardiac Output During Exercise by Inert Gas Rebreathing Technique: A New Tool for Heart Failure Evaluation J. Am. Coll. Cardiol., November 1, 2005; 46(9): 1779 - 1781. [Full Text] [PDF]
|
|
|
|
 |
|
 A. M Jones, D. P Wilkerson, and I. T Campbell Nitric oxide synthase inhibition with L-NAME reduces maximal oxygen uptake but not gas exchange threshold during incremental cycle exercise in man J. Physiol., October 1, 2004; 560(1): 329 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Belardinelli, F. Lacalaprice, F. Carle, A. Minnucci, G. Cianci, G. Perna, and G. D'Eusanio Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing Eur. Heart J., July 2, 2003; 24(14): 1304 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 ATS/ACCP Statement on Cardiopulmonary Exercise Testing Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 211 - 277. [Full Text] [PDF]
|
|
|
|
|
|
X.-G. Sun, J. E. Hansen, N. Garatachea, T. W. Storer, and K. Wasserman Ventilatory Efficiency during Exercise in Healthy Subjects Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1443 - 1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.P. Nicholls, C. O'Dochartaigh, and M.S. Riley Circulatory power--a new perspective on an old friend Eur. Heart J., August 2, 2002; 23(16): 1242 - 1245. [PDF]
|
|
|
|
|
|
S. Godfrey, H. Kazemi, D. Systrom, K. Wasserman, X.-G. Sun, J. E. Hansen, H. Ting, and W. W. Stringer Carbon Dioxide Pressure-Concentration Relationship in Arterial and Mixed Venous Blood J Appl Physiol, November 1, 2001; 91(5): 2412 - 2414. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bigi, A. Desideri, R. Rambaldi, L. Cortigiani, C. Sponzilli, and C. Fiorentini Angiographic and Prognostic Correlates of Cardiac Output by Cardiopulmonary Exercise Testing in Patients With Anterior Myocardial Infarction Chest, September 1, 2001; 120(3): 825 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-G. Sun, J. E. Hansen, R. J. Oudiz, and K. Wasserman Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension Circulation, July 24, 2001; 104(4): 429 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Ozyener, H B Rossiter, S A Ward, and B J Whipp Influence of exercise intensity on the on- and off-transient kinetics of pulmonary oxygen uptake in humans J. Physiol., June 15, 2001; 533(3): 891 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Bearden and R. J. Moffatt {V}O2 and heart rate kinetics in cycling: transitions from an elevated baseline J Appl Physiol, June 1, 2001; 90(6): 2081 - 2087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-G. Sun, J. E. Hansen, W. W. Stringer, H. Ting, and K. Wasserman Carbon dioxide pressure-concentration relationship in arterial and mixed venous blood during exercise J Appl Physiol, May 1, 2001; 90(5): 1798 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-G. Sun, J. E. Hansen, H. Ting, M.-L. Chuang, W. W. Stringer, D. Adame, and K. Wasserman Comparison of Exercise Cardiac Output by the Fick Principle Using Oxygen and Carbon Dioxide Chest, September 1, 2000; 118(3): 631 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wasserman and R. Oudiz Overdosing with prostacyclin in primary pulmonary hypertension J. Am. Coll. Cardiol., June 1, 2000; 35(7): 1995 - 1996. [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Chuang, H. Ting, T. Otsuka, X.-G. Sun, F. Y. L. Chiu, W. L. Beaver, J. E. Hansen, D. A. Lewis, and K. Wasserman Aerobically generated CO2 stored during early exercise J Appl Physiol, September 1, 1999; 87(3): 1048 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G P Armstrong, S G Carlier, K Fukamachi, J D Thomas, and T H Marwick Estimation of cardiac reserve by peak power: validation and initial application of a simplified index Heart, September 1, 1999; 82(3): 357 - 364. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
