| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Environmental Health Sciences and 2 Anesthesiology, The Johns Hopkins University, Baltimore, Maryland 21205
Received 26 February 1996; accepted in final form 22 October 1996.
Tankersley, Clarke G., Robert S. Fitzgerald, Roy C. Levitt,
Wayne A. Mitzner, Susan L. Ewart, and Steven R. Kleeberger. Genetic control of differential baseline breathing pattern. J. Appl. Physiol. 82(3): 874-881, 1997.
The purpose of the present study was to determine the genetic
control of baseline breathing pattern by examining the mode of
inheritance between two inbred murine strains with differential
breathing characteristics. Specifically, the rapid, shallow phenotype
of the C57BL/6J (B6) strain is consistently distinct from the
slow, deep phenotype of the C3H/HeJ (C3) strain. The response
distributions of segregant and nonsegregant progeny were compared with
the two progenitor strains to determine the mode of inheritance for
each ventilatory characteristic. The BXH recombinant inbred (RI)
strains derived from the B6 and C3 progenitors were examined to
establish strain distribution patterns for each ventilatory trait. To
establish the mode of inheritance, baseline breathing frequency (f),
tidal volume, and inspiratory time
(TI) were measured five times
in each of 178 mature male animals from the two progenitor strains and
their progeny by using whole body plethysmography. With respect to f
and TI, the two progenitor strains were consistently distinct, and segregation analyses of the
inheritance pattern suggest that the most parsimonious genetic model
for response distributions of f and
TI is a two-loci model. In
similar experiments conducted on 82 mature male animals from 12 BXH RI
strains, each parental phenotype was represented by one or more of the
RI strains. Intermediate phenotypes emerged to confirm the likelihood
that parental strain differences in f and
TI were determined by more than
one locus. Taken together, these studies suggest that the phenotypic
difference in baseline respiratory timing between male B6 and C3 mice
is best explained by a genetic model that considers at least two loci
as major determinants.
inbred mice; control of ventilation; respiratory timing; breathing frequency; BXH recombinant inbred strains
This article has been cited by other articles:
|
|
 |
|
  M. C. Cheung, R. M. Carey, and M. Wachowiak A Method for Generating Natural and User-Defined Sniffing Patterns in Anesthetized or Reduced Preparations Chem Senses, January 1, 2009; 34(1): 63 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Dodd-o, M. Hristopoulos, D. Scharfstein, R. Brower, P. Hassoun, L. S. King, P. Becker, M. Liu, W. Wang, H. T. Hassoun, et al. Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse model Am J Physiol Lung Cell Mol Physiol, January 1, 2009; 296(1): L3 - L11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Howden, E. Liu, L. Miller-DeGraff, H. L. Keener, C. Walker, J. A. Clark, P. H. Myers, D. C. Rouse, T. Wiltshire, and S. R. Kleeberger The genetic contribution to heart rate and heart rate variability in quiescent mice Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H59 - H68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Mitzner, Z. Hantos, C. Irvin, and C. Tankersley Airway Responsiveness Should Be a Measurement of the Responsiveness of Airways Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 215 - 215. [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Ward, E. Moore, K. Noon, N. Spassil, E. Keenan, T. L. Ivanco, and J. C. LaManna Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains J Appl Physiol, May 1, 2007; 102(5): 1927 - 1935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. P. Kodavanti, M. C. Schladweiler, A. D. Ledbetter, R. V. Ortuno, M. Suffia, P. Evansky, J. H. Richards, R. H. Jaskot, R. Thomas, E. Karoly, et al. The Spontaneously Hypertensive Rat: An Experimental Model of Sulfur Dioxide-Induced Airways Disease Toxicol. Sci., November 1, 2006; 94(1): 193 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. del Barco Barrantes, A. Montero-Pedrazuela, A. Guadano-Ferraz, M.-J. Obregon, R. Martinez de Mena, V. Gailus-Durner, H. Fuchs, T. J. Franz, S. Kalaydjiev, M. Klempt, et al. Generation and Characterization of dickkopf3 Mutant Mice. Mol. Cell. Biol., March 1, 2006; 26(6): 2317 - 2326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Reinhard, B. Meyer, H. Fuchs, T. Stoeger, G. Eder, F. Ruschendorf, J. Heyder, P. Nurnberg, M. H. de Angelis, and H. Schulz Genomewide Linkage Analysis Identifies Novel Genetic Loci for Lung Function in Mice Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 880 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. O'Neal III, E. T. Spiegel, K. H. Chon, and I. C. Solomon Time-Frequency Representation of Inspiratory Motor Output in Anesthetized C57BL/6 Mice In Vivo J Neurophysiol, March 1, 2005; 93(3): 1762 - 1775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Friedman, A. Haines, K. Klann, L. Gallaugher, L. Salibra, F. Han, and K. P. Strohl Ventilatory behavior during sleep among A/J and C57BL/6J mouse strains J Appl Physiol, November 1, 2004; 97(5): 1787 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Choudhury, M. R. Wilson, M. E. Goddard, K. P. O'Dea, and M. Takata Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L902 - L910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Izumizaki, M. Pokorski, and I. Homma Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse J Appl Physiol, October 1, 2004; 97(4): 1401 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley and K. W. Broman Interactions in hypoxic and hypercapnic breathing are genetically linked to mouse chromosomes 1 and 5 J Appl Physiol, July 1, 2004; 97(1): 77 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Adler, G. Cieslewicz, and C. G. Irvin Unrestrained plethysmography is an unreliable measure of airway responsiveness in BALB/c and C57BL/6 mice J Appl Physiol, July 1, 2004; 97(1): 286 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Wilson, S. Choudhury, M. E. Goddard, K. P. O'Dea, A. G. Nicholson, and M. Takata High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury J Appl Physiol, October 1, 2003; 95(4): 1385 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. U. Gurkan, C. O'Donnell, R. Brower, E. Ruckdeschel, and P. M. Becker Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L710 - L718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Mitzner, C. Tankersley, L. K. A. Lundblad, A. Adler, C. G. Irvin, and J. H. T. Bates Interpreting Penh in mice J Appl Physiol, February 1, 2003; 94(2): 828 - 832. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dauger, L. Ferkdadji, G. Saumon, G. Vardon, M. Peuchmaur, C. Gaultier, and J. Gallego Neonatal Exposure to 65% Oxygen Durably Impairs Lung Architecture and Breathing Pattern in Adult Mice Chest, February 1, 2003; 123(2): 530 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Hodges, H. V. Forster, P. E. Papanek, M. R. Dwinell, and G. E. Hogan Ventilatory phenotypes among four strains of adult rats J Appl Physiol, September 1, 2002; 93(3): 974 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Han, S. Subramanian, E. R. Price, J. Nadeau, and K. P. Strohl Periodic breathing in the mouse J Appl Physiol, March 1, 2002; 92(3): 1133 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, R. Irizarry, S. Flanders, and R. Rabold Functional Genomics of Sleep and Circadian Rhythm: Selected Contribution: Circadian rhythm variation in activity, body temperature, and heart rate between C3H/HeJ and C57BL/6J inbred strains J Appl Physiol, February 1, 2002; 92(2): 870 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Renolleau, S. Dauger, F. Autret, G. Vardon, C. Gaultier, and J. Gallego Maturation of baseline breathing and of hypercapnic and hypoxic ventilatory responses in newborn mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1746 - R1753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Burnet, M. Bevengut, F. Chakri, C. Bou-Flores, P. Coulon, S. Gaytan, R. Pasaro, and G. Hilaire Altered Respiratory Activity and Respiratory Regulations in Adult Monoamine Oxidase A-Deficient Mice J. Neurosci., July 15, 2001; 21(14): 5212 - 5221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Fuller, A. G. Zabka, T. L. Baker, and G. S. Mitchell Physiological and Genomic Consequences of Intermittent Hypoxia: Selected Contribution: Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia J Appl Physiol, May 1, 2001; 90(5): 2001 - 2006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. FULLER, T. L. BAKER, M. BEHAN, and G. S. MITCHELL Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat Physiol Genomics, January 19, 2001; 4(3): 175 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. MITZNER, R. BROWN, and W. LEE In vivo measurement of lung volumes in mice Physiol Genomics, January 19, 2001; 4(3): 215 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-D. Held and S. Uhlig Basal lung mechanics and airway and pulmonary vascular responsiveness in different inbred mouse strains J Appl Physiol, June 1, 2000; 88(6): 2192 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, R. C. Elston, and A. H. Schnell Genetic determinants of acute hypoxic ventilation: patterns of inheritance in mice J Appl Physiol, June 1, 2000; 88(6): 2310 - 2318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Robinson, H. Kwok, B. M. Adams, K. C. Peebles, and G. D. Funk Development of the ventilatory response to hypoxia in Swiss CD-1 mice J Appl Physiol, May 1, 2000; 88(5): 1907 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, R. Rabold, and W. Mitzner Differential lung mechanics are genetically determined in inbred murine strains J Appl Physiol, June 1, 1999; 86(6): 1764 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, D. A. DiSilvestre, A. E. Jedlicka, H. M. Wilkins, and L. Zhang Differential inspiratory timing is genetically linked to mouse chromosome 3 J Appl Physiol, July 1, 1998; 85(1): 360 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Mitzner and C. Tankersley Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 340 - 342. [Full Text] [PDF]
|
|
|
|
|
|
J. V. Weil, T. Stevens, C. K. Pickett, K. Tatsumi, M. G. Dickinson, C. R. Jacoby, and D. M. Rodman Strain-associated differences in hypoxic chemosensitivity of the carotid body in rats Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L767 - L774. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
