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J Appl Physiol 82: 841-845, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 3, pp. 841-845, March 1997
SYSTEMIC CIRCULATION AND FLUID BALANCE

Bronchial vasodilatory response to ionic and nonionic contrast media

Elisabeth M. Baile, Lu Wang, Lorraine Verburgt, and Peter D. Paré

University of British Columbia Pulmonary Research Laboratory, St Paul's Hospital, Vancouver, British Columbia, Canada, V6Z 1Y6

Received 13 August 1996; accepted in final form 5 November 1996.

Baile, Elisabeth M., Lu Wang, Lorraine Verburgt, and Peter D. Paré. Bronchial vasodilatory response to ionic and nonionic contrast media. J. Appl. Physiol. 82(3): 841-845, 1997.---It has recently been shown that bronchial arterial injection of conventional contrast medium causes a significant increase in bronchial blood flow (Qbr) and that this response is partially attenuated after infusion of Nomega -nitro-L-arginine (L-NNA). However, the precise mechanism for this increase in Qbr is unknown. In this study we examined the effect of bronchial arterial injection of conventional ionic as well as nonionic contrast media. We measured Qbr in nine anesthetized, ventilated, open-chest sheep. Qbr was recorded before (baseline) and at the peak response to injection of 0.5 ml of either 0.9% saline (control; isosmolar with plasma), Omnipaque 300 (iohexol; nonionic), Conray 66 (sodium iothalamate; ionic), or 50% dextrose (viscous control).

sheep; ultrasonic flow probe; Nomega -nitro-L-arginine; nitric oxide; osmolality

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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