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Department of Physiology, Midwestern University, Downers Grove, Illinois 60515
Received 7 May 1996; accepted in final form 28 October 1996.
Osborn, Brett A., June T. Daar, Richard A. Laddaga, Fred D. Romano, and Dennis J. Paulson. Exercise training increases sarcolemmal GLUT-4 protein and mRNA content in diabetic heart. J. Appl. Physiol. 82(3): 828-834, 1997.
This study determined whether dynamic exercise training of
diabetic rats would increase the expression of the GLUT-4 glucose
transport protein in prepared cardiac sarcolemmal membranes. Four
groups were compared: sedentary control, sedentary diabetic, trained
control, and trained diabetic. Diabetes was induced by intravenous
streptozotocin (60 mg/kg). Trained control and diabetic rats were run
on a treadmill for 60 min, 27 m/min, 10% grade, 6 days/wk for 10 wk.
Sarcolemmal membranes were isolated by using differential
centrifugation, and the activity of sarcolemmal
K+-p-nitrophenylphosphatase
( pNPPase; an indicator of
Na+-K+-adenosinetriphosphatase
activity) was quantified. Hearts from the sedentary diabetic group
exhibited a significant depression of sarcolemmal pNPPase
activity. Exercise training did not significantly alter
pNPPase activity. Sedentary diabetic rats exhibited an 84 and 58% decrease in GLUT-4 protein and mRNA, respectively, relative to
control rats. In the trained diabetic animals, sarcolemmal GLUT-4
protein levels were only reduced by 50% relative to control values,
whereas GLUT-4 mRNA were returned to control levels. The increase in
myocardial sarcolemmal GLUT-4 may be beneficial to the diabetic heart
by enhancing myocardial glucose oxidation and cardiac performance
myocardial glucose oxidation; diabetic cardiomyopathy
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