Journal of Applied Physiology Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 82: 819-827, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fitzgerald, R. S.
Right arrow Articles by Ide, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fitzgerald, R. S.
Right arrow Articles by Ide, T.

Journal of Applied Physiology
Vol. 82, No. 3, pp. 819-827, March 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Further cholinergic aspects of carotid body chemotransduction of hypoxia in cats

Robert S. Fitzgerald1,2,3, Machiko Shirahata1,4, and Tohru Ide1

Departments of 1 Environmental Health Sciences, 2 Physiology, 3 Medicine, and 4 Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205

Received 21 August 1995; accepted in final form 27 November 1996.

Fitzgerald, Robert S., Machiko Shirahata, and Tohru Ide. Further cholinergic aspects of carotid body chemotransduction of hypoxia in cats. J. Appl. Physiol. 82(3): 819-827, 1997.---From the 1930s into the 1970s, the role of acetylcholine (ACh) in the carotid body's chemotransduction of hypoxia was debated. Since the late 1970s, the issue has been pursued only intermittently or not at all. The purpose of this study was to test again with a new preparation the hypothesis that ACh is an excitatory neurotransmitter in the cat carotid body's chemotransduction of hypoxia. We tested the effect of the specific nicotinic blocker mecamylamine and the muscarinic blocker of all five muscarinic receptors, atropine. We further tested the effects of M1 and M2 muscarinic-receptor blockers. The carotid body region was selectively perfused with hypoxic Krebs-Ringer bicarbonate (KRB) solutions that were blocker free or contained varying doses of the blockers. Both mecamylamine and atropine reduced the response to hypoxic KRB in a dose-related manner. The M2 muscarinic-receptor blockers gallamine and AFDX 116 increased the response to hypoxic KRB, whereas the M1 muscarinic-receptor blocker pirenzepine reduced the response to hypoxic KRB. These data are consistent with an excitatory role for ACh in the carotid body chemotransduction of hypoxia in the cat.

acetylcholine; mecamylamine; atropine; gallamine; pirenzepine; AFDX 116

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
D. F. Donnelly
Spontaneous action potential generation due to persistent sodium channel currents in simulated carotid body afferent fibers
J Appl Physiol, May 1, 2008; 104(5): 1394 - 1401.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. H Vidruk, E B. Olson Jr, L. Ling, and G. S Mitchell
Responses of single-unit carotid body chemoreceptors in adult rats
J. Physiol., February 15, 2001; 531(1): 165 - 170.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Zhang, H. Zhong, C. Vollmer, and C. A Nurse
Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors
J. Physiol., May 15, 2000; 525(1): 143 - 158.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Bairam, H. Neji, and F. Marchal
Cholinergic dopamine release from the in vitro rabbit carotid body
J Appl Physiol, May 1, 2000; 88(5): 1737 - 1742.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online