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1 Metabolism,
Received 13 September 1996; accepted in final form 1 November
1996.
Ferrando, Arny A., Kevin D. Tipton, Marcas M. Bamman, and
Robert R. Wolfe. Resistance exercise maintains skeletal muscle protein synthesis during bed rest. J. Appl.
Physiol. 82(3): 807-810, 1997.
spaceflight; microgravity; biopsy
Spaceflight
results in a loss of lean body mass and muscular strength. A
ground-based model for microgravity, bed rest, results in a loss of
lean body mass due to a decrease in muscle protein synthesis (MPS).
Resistance training is suggested as a proposed countermeasure for
spaceflight-induced atrophy because it is known to increase both MPS
and skeletal muscle strength. We therefore hypothesized that scheduled
resistance training throughout bed rest would ameliorate the decrease
in MPS. Two groups of healthy volunteers were studied during 14 days of
simulated microgravity. One group adhered to strict bed rest (BR;
n = 5), whereas a second group engaged
in leg resistance exercise every other day throughout bed rest (BREx;
n = 6). MPS was determined directly by
the incorporation of infused
L-[ring-13C6]phenylalanine
into vastus lateralis protein. After 14 days of bed rest, MPS in the
BREx group did not change and was significantly greater than in the BR
group. Thus moderate-resistance exercise can counteract the decrease in
MPS during bed rest.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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