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J Appl Physiol 82: 760-764, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 3, pp. 760-764, March 1997
EXERCISE AND MUSCLE

Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans

Lennart Jungersten, Anneli Ambring, Björn Wall, and Åke Wennmalm

Department of Clinical Physiology, Göteborg University, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden

Received 25 June 1996; accepted in final form 4 November 1996.

Jungersten, Lennart, Anneli Ambring, Björn Wall, and Åke Wennmalm. Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J. Appl. Physiol. 82(3): 760-764, 1997.---We analyzed nitrate, a major stable end product of nitric oxide (NO) metabolism in vivo in plasma and urine from groups of healthy subjects with different working capacities. Resting plasma nitrate was higher in athletic subjects than in nonathletic controls [45 ± 2 vs. 34 ± 2 (SE) µM; P < 0.01]. In other subjects, both the resting plasma nitrate level (r = 0.53; P < 0.01) and the urinary excretion of nitrate at rest (r = 0.46; P < 0.01) correlated to the subjects' peak work rates, as determined by bicycle ergometry. Two hours of physical exercise elevated plasma nitrate by 18 ± 4 (P < 0.01) and 16 ± 6% (P < 0.01), respectively, in athletes and nonathletes, compared with resting nitrate before exercise. We conclude that physical fitness and formation of NO at rest are positively linked to each other. Furthermore, a single session of exercise elicits an acute elevation of NO formation. The observed positive relation between physical exercise and NO formation may help to explain the beneficial effects of physical exercise on cardiovascular health.

nitric oxide synthase; nitrate; vascular system; shear stress

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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