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Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110
Received 1 October 1996; accepted in final form 18 November 1996.
Nakatani, Akira, Dong-Ho Han, Polly A. Hansen, Lorraine A. Nolte, Helen H. Host, Robert C. Hickner, and John O. Holloszy. Effect of endurance exercise training on muscle glycogen
supercompensation in rats. J. Appl.
Physiol. 82(2): 711-715, 1997.
The purpose of this study was to test the hypothesis that the rate and extent of
glycogen supercompensation in skeletal muscle are increased by
endurance exercise training. Rats were trained by using a 5-wk-long swimming program in which the duration of swimming was gradually increased to 6 h/day over 3 wk and then maintained at 6 h/day for an
additional 2 wk. Glycogen repletion was measured in trained and
untrained rats after a glycogen-depleting bout of exercise. The rats
were given a rodent chow diet plus 5% sucrose in their drinking water
ad libitum during the recovery period. There were remarkable
differences in both the rates of glycogen accumulation and the glycogen
concentrations attained in the two groups. The concentration of
glycogen in epitrochlearis muscle averaged 13.1 ± 0.9 mg/g wet wt
in the untrained group and 31.7 ± 2.7 mg/g in the trained group
(P < 0.001) 24 h after the exercise.
This difference could not be explained by a training effect on glycogen
synthase. The training induced ~50% increases in muscle GLUT-4
glucose transporter protein and in hexokinase activity in
epitrochlearis muscles. We conclude that endurance exercise training
results in increases in both the rate and magnitude of muscle glycogen
supercompensation in rats.
glucose transporter isoform 4; glucose transporter; glycogen synthase; hexokinase
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