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J Appl Physiol 82: 686-692, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 2, pp. 686-692, February 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

Nitric oxide and beta -adrenergic agonist-induced bronchial arterial vasodilation

Nirmal B. Charan1,3, Shane R. Johnson1,3, S. Lakshminarayan2,3, William H. Thompson1,3, and Paula Carvalho1,3

1 Pulmonary Research Laboratory, Veterans Affairs Medical Center, Boise, Idaho 83702; 2 Veterans Affairs Medical Center, Seattle, Washington 98108; and 3 Division of Pulmonary/Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195

Received 29 July 1996; accepted in final form 15 October 1996.

Charan, Nirmal B., Shane R. Johnson, S. Lakshminarayan, William H. Thompson, and Paula Carvalho. Nitric oxide and beta -adrenergic agonist-induced bronchial arterial vasodilation. J. Appl. Physiol. 82(2): 686-692, 1997.---In anesthetized sheep, we measured bronchial blood flow (Qbr) by an ultrasonic flow probe to investigate the interaction between inhaled nitric oxide (NO; 100 parts/million) given for 5 min and 5 ml of aerosolized isoetharine (1.49 × 10-2 M concentration). NO and isoetharine increased Qbr from 26.5 ± 6.5 to 39.1 (SE) ± 10.6 and 39.7 ± 10.7 ml/min, respectively (n = 5). Administration of NO immediately after isoetharine further increased Qbr to 57.3 ± 15.1 ml/min. NO synthase inhibitor Nomega -nitro-L-arginine methyl ester hydrochloride (L-NAME; 30 mg/kg, in 20 ml saline given iv) decreased Qbr to 14.6 ± 2.6 ml/min. NO given three times alternately with isoetharine progressively increased Qbr from 14.6 ± 2.6 to 74.3 ± 17.0 ml/min, suggesting that NO and isoetharine potentiate vasodilator effects of each other. In three other sheep, after L-NAME, three sequential doses of isoetharine increased Qbr from 10.2 ± 3.4 to 11.5 ± 5.7, 11.7 ± 4.7, and 13.3 ± 5.7 ml/min, respectively, indicating that effects of isoetharine are predominantly mediated through synthesis of NO. When this was followed by three sequential administrations of NO, Qbr increased by 146, 172, and 185%, respectively. Thus in the bronchial circulation there seems to be a close interaction between adenosine 3',5'-cyclic monophosphate- and guanosine 3',5'-cyclic monophosphate-mediated vasodilatation.

bronchial circulation; bronchial blood flow; isoetharine; adenosine 3',5'-cyclic monophosphate; guanosine 3',5'-cyclic monophosphate

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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