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Departments of 1 Anesthesiology, 2 Physiology and Biophysics, and 3 Medicine, University of Washington School of Medicine, Seattle, Washington 98195
Received 21 December 1995; accepted in final form 18 October 1996.
Walther, Sten M., Karen B. Domino, Robb W. Glenny, Nayak L. Polissar, and Michael P. Hlastala. Pulmonary blood flow distribution has a hilar-to-peripheral gradient in awake, prone sheep.
J. Appl. Physiol. 82(2): 678-685, 1997.
We examined the pulmonary blood flow distribution with
intravenous fluorescent microspheres (15 µm) in nine prone,
unanesthetized, lambs. Lungs flushed free of blood were air-dried at
total lung capacity and sectioned into
~2-cm3 pieces. The pieces were
weighed, identified by lobe, and assigned spatial coordinates.
Fluorescence was read on a spectrophotometer, and signals were
corrected for piece weight and normalized to mean flow. Pulmonary blood
flow heterogeneity was assessed by using the coefficient of variation
of the flow data. The number of pieces (±SD) analyzed were 1,249 ± 150/animal. Heterogeneity of blood flow was 29.5 ± 6.5%
(coefficient of variation = SD/mean). Pulmonary blood flow decreased
with distance from hilus (P < 0.002) but did not change significantly with vertical height. Distance from
the hilus was the best predictor of pulmonary blood flow (R2 = 0.201) and,
together with spatial coordinates and lobe, accounted for 33.7 ± 12.0% of blood flow variability. We conclude that pulmonary blood flow
in the awake, prone sheep is distributed with a hilar-to-peripheral gradient but no significant vertical gradient.
lung; regional pulmonary blood flow; heterogeneity; gravitational gradient; methods; fluorescence; microspheres;
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