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Departments of Medical Physiology and Sports Medicine and of Haematology, University of Utrecht, 3508 TA Utrecht, The Netherlands
Received 19 March 1996; accepted in final form 24 October 1996.
Van den Burg, P. J. M., J. E. H. Hospers, M. Van Vliet, W. L. Mosterd, B. N. Bouma, and I. A. Huisveld. Effect of endurance training and seasonal fluctuation on coagulation and fibrinolysis in
young sedentary men. J. Appl. Physiol.
82(2): 613-620, 1997.
The effect of 12 wk of submaximal training
on hemostatic variables was studied in 20 young sedentary men (Tr) and
19 nontraining matched controls (Con). After training, a more
pronounced increase in factor VIII coagulant activity
(P < 0.01), reflected in a decrease in activated partial thromboplastin time
(P < 0.01) during maximal exercise,
was seen. Both basal plasminogen activator inhibitor 1 antigen (PAI-1
Ag) and activity (PAI-1 Act; P < 0.05), as well as basal and exercise-induced tissue-type plasminogen
activator antigen (t-PA Ag; P < 0.05), were decreased after training. The overall effect on
fibrinolysis was reflected in an increase in the t-PA Act/t-PA Ag ratio
in the Tr group. In contrast, during the same period (February-June),
the Con group demonstrated an increase in basal PAI-1 Ag and PAI-1 Act
(P < 0.05), together with an
increase in basal and exercise-induced t-PA Ag
(P < 0.05). Both basal and
exercise-induced t-PA Act were unchanged, but t-PA Act/t-PA Ag was
decreased (P < 0.05) in the Con
group. We conclude that physical training promotes both coagulation and
fibrinolytic potential during exercise and may reverse unfavorable
seasonal effects on fibrinolysis.
exercise; training; season; hemostasis
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