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1 Department of Surgery,
Received 9 July 1996; accepted in final form 30 September 1996.
Turnage, Richard H., John L. LaNoue, Kevin M. Kadesky, Yan
Meng, and Stuart I. Myers. Thromboxane
A2 mediates increased pulmonary
microvascular permeability after intestinal reperfusion. J. Appl. Physiol. 82(2): 592-598, 1997.
capillary filtration coefficient; hydrostatic pressure; pulmonary
vascular resistance; pulmonary edema
This study examines the hypothesis that intestinal reperfusion
(IR)-induced pulmonary thromboxane A2
(TxA2) release increases local
microvascular permeability and induces pulmonary vasoconstriction.
Sprague-Dawley rats underwent 120 min of intestinal ischemia and 60 min
of IR. Sham-operated animals (Sham) served as controls. After IR or
Sham, the pulmonary vessels were cannulated, and the lungs were
perfused in vitro with Krebs buffer. Microvascular permeability was
quantitated by determining the filtration coefficient
(Kf),
and pulmonary arterial (Ppa), venous (Ppv), and capillary (Ppc)
pressures were measured to calculate vascular resistance (Rt). After
baseline measurements, imidazole
(TxA2 synthase inhibitor) or
SQ-29,548 (TxA2-receptor
antagonist) was added to the perfusate; then
Kf, Ppa, Ppv, and Ppc were again measured. The
Kf
of lungs from IR animals was four times greater than that of Sham
(P = 0.001), and Rt was 63% greater
in the injured group (P = 0.01). Pc of IR lungs was twice that of controls (5.4 ± 1.0 vs. 2.83 ± 0.3 mmHg, IR vs. Sham, respectively; P < 0.05). Imidazole or SQ-29,548 returned
Kf
to baseline measurements (P < 0.05)
and reduced Rt by 23 and 17%, respectively
(P < 0.05). IR-induced increases in Pc were only slightly reduced by 500 µg/ml imidazole (14%;
P = 0.05) but unaffected by lower
doses of imidazole (5 or 50 µg/ml) or SQ-29,548. These data suggest
that IR-induced pulmonary edema is caused by both increased
microvascular permeability and increased hydrostatic pressure and that
these changes are due, at least in part, to the ongoing release of
TxA2.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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