Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 82: 571-576, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 2, pp. 571-576, February 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Effect of running intensity on intestinal permeability

Kay L. Pals, Ray-Tai Chang, Alan J. Ryan, and Carl V. Gisolfi

Department of Exercise Science, University of Iowa, Iowa City, Iowa 52242-1111

Received 22 May 1996; accepted in final form 16 October 1996.

Pals, Kay L., Ray-Tai Chang, Alan J. Ryan, and Carl V. Gisolfi. Effect of running intensity on intestinal permeability. J. Appl. Physiol. 82(2): 571-576, 1997.---Enhanced intestinal permeability has been associated with gastrointestinal disorders in long-distance runners. The primary purpose of this study was to evaluate the effect of running intensity on small intestinal permeability by using the lactulose and rhamnose differential urinary excretion test. Secondary purposes included assessing the relationship between small intestinal permeability and gastrointestinal symptoms and evaluating gastric damage by using sucrose as a probe. Six healthy volunteers [5 men, 1 woman; age = 30 ± 2 yr; peak O2 uptake (VO2 peak) = 57.7 ± 2.1 ml · kg-1 · min-1] rested or performed treadmill exercise at 40, 60, or 80% VO2 peak for 60 min in a moderate environment (22°C, 50% relative humidity). At 30 min into rest or exercise, the permeability test solution (5 g sucrose, 5 g lactulose, 2 g rhamnose in 50 ml water; ~800 mosM) was ingested. Urinary excretion rates (6 h) of the lactulose-to-rhamnose ratio were used to assess small intestinal permeability, and concentrations of each probe were determined by using high-performance liquid chromatography. Running at 80% VO2 peak increased (P < 0.05) small intestinal permeability compared with rest, 40, and 60% VO2 peak with mean values expressed as percent recovery of ingested dose of 0.107 ± 0.021 (SE), 0.048 ± 0.009, 0.056 ± 0.005, and 0.064 ± 0.010%, respectively. Increases in small intestinal permeability did not result in a higher prevalence of gastrointestinal symptoms, and urinary recovery of sucrose did not reflect increased gastric permeability. The significance and mechanisms involved in increased small intestinal permeability after high-intensity running merit further investigation.

exercise; lactulose; rhamnose; human

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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