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Department of Exercise Science, University of Iowa, Iowa City, Iowa 52242-1111
Received 22 May 1996; accepted in final form 16 October 1996.
Pals, Kay L., Ray-Tai Chang, Alan J. Ryan, and Carl V. Gisolfi. Effect of running intensity on intestinal permeability. J. Appl. Physiol. 82(2): 571-576, 1997.
Enhanced intestinal permeability has been associated with
gastrointestinal disorders in long-distance runners. The primary
purpose of this study was to evaluate the effect of running intensity
on small intestinal permeability by using the lactulose and rhamnose
differential urinary excretion test. Secondary purposes included
assessing the relationship between small intestinal permeability and
gastrointestinal symptoms and evaluating gastric damage by using
sucrose as a probe. Six healthy volunteers [5 men, 1 woman; age = 30 ± 2 yr; peak O2 uptake
(
O2 peak) = 57.7 ± 2.1 ml · kg
1 · min1]
rested or performed treadmill exercise at 40, 60, or 80%
O2 peak for 60 min in a moderate environment (22°C, 50% relative
humidity). At 30 min into rest or exercise, the permeability test
solution (5 g sucrose, 5 g lactulose, 2 g rhamnose in 50 ml water;
~800 mosM) was ingested. Urinary excretion rates (6 h) of the
lactulose-to-rhamnose ratio were used to assess small intestinal
permeability, and concentrations of each probe were determined by using
high-performance liquid chromatography. Running at 80%
O2 peak
increased (P < 0.05) small
intestinal permeability compared with rest, 40, and 60% O2 peak
with mean values expressed as percent recovery of ingested dose of
0.107 ± 0.021 (SE), 0.048 ± 0.009, 0.056 ± 0.005, and 0.064 ± 0.010%, respectively. Increases in small intestinal permeability did not result in a higher prevalence of gastrointestinal symptoms, and
urinary recovery of sucrose did not reflect increased gastric permeability. The significance and mechanisms involved in increased small intestinal permeability after high-intensity running merit further investigation.
exercise; lactulose; rhamnose; human
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