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J Appl Physiol 82: 563-570, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 2, pp. 563-570, February 1997
GAS EXCHANGE, MECHANICS, AND AIRWAYS

Adaptation of the doubly labeled water method for subjects consuming isotopically enriched water

Randall J. Gretebeck1, Dale A. Schoeller2, Rick A. Socki3, Janis Davis-Street1, Everett K. Gibson3, Leslie O. Schulz4, and Helen W. Lane1

1 Nutritional Biochemistry and 3 Stable Isotope Laboratories, Space and Life Sciences Directorate, National Aeronautics and Space Administration/Johnson Space Center, Houston, Texas 77058; 2 The Committee on Human Nutrition and Nutritional Biology, University of Chicago, Department of Medicine, Chicago, Illinois 60637; and 4 Health Sciences, University of Wisconsin, Milwaukee, Wisconsin 53201

Received 20 May 1996; accepted in final form 26 August 1996.

Gretebeck, Randall J., Dale A. Schoeller, Rick A. Socki, Janis Davis-Street, Everett K. Gibson, Leslie O. Schulz, and Helen W. Lane. Adaptation of the doubly labeled water method for subjects consuming isotopically enriched water. J. Appl. Physiol. 82(2): 563-570, 1997.---The use of doubly labeled water (DLW) to measure energy expenditure is subject to error if the background abundance of the oxygen and hydrogen isotope tracers changes during the test period. This study evaluated the accuracy and precision of different methods by which such background isotope changes can be corrected, including a modified method that allows prediction of the baseline that would be achieved if subjects were to consume water from a given source indefinitely. Subjects in this study were eight women (4 test subjects and 4 control subjects) who consumed for 28 days water enriched to resemble drinking water aboard the United States space shuttle. Test subjects and control subjects were given a DLW dose on days 1 and 15, respectively. The change to an enriched water source produced a bias in expenditure calculations that exceeded 2.9 MJ/day (35%), relative to calculations from intake-balance. The proposed correction based on the predicted final abundance of 18O and deuterium after equilibration to the new water source eliminated this bias, as did the traditional use of a control group. This new modified correction method is advantageous under field conditions when subject numbers are limited.

deuterium; oxygen-18; mass spectrometry; energy expenditure

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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