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Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
Received 9 July 1996; accepted in final form 16 October 1996.
Tansley, J. G., C. Clar, M. E. F. Pedersen, and P. A. Robbins. Human ventilatory response to acute hyperoxia during and
after 8 h of both isocapnic and poikilocapnic hypoxia.
J. Appl. Physiol. 82(2): 513-519, 1997.
During 8 h of either isocapnic or poikilocapnic hypoxia,
there may be a rise in ventilation
(
E) that
cannot be rapidly reversed with a return to higher
PO2 (L. S. G. E. Howard and P. A. Robbins. J. Appl. Physiol. 78:
1098-1107, 1995). To investigate this further, three
protocols were compared: 1) 8-h
isocapnic hypoxia [end-tidal
PCO2
(PETCO2 ) held at
prestudy value, end-tidal PO2
(PETO2) = 55 Torr],
followed by 8-h isocapnic euoxia
(PETO2 = 100 Torr);
2) 8-h poikilocapnic
hypoxia followed by 8-h poikilocapnic euoxia; and
3) 16-h air-breathing control.
Before and at intervals throughout each protocol, the
E response to eucapnic
hyperoxia (PETCO2 held
1-2 Torr above prestudy value,
PETO2 = 300 Torr) was
determined. There was a significant rise in hyperoxic E over 8 h
during both forms of hypoxia (P < 0.05, analysis of variance) that persisted during the subsequent 8-h
euoxic period (P < 0.05, analysis of
variance). These results support the notion that an 8-h period of
hypoxia increases subsequent
hyperoxic E, even if acid-base changes have been minimized through maintenance of
isocapnia during the hypoxic period.
hypoxic ventilatory response; hyperoxic ventilatory response; altitude; acclimatization
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