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Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46202
Received 20 May 1996; accepted in final form 25 September 1996.
Lash, Julia M., and H. Glenn Bohlen. Time- and
order-dependent changes in functional and NO-mediated dilation during exercise training. J. Appl. Physiol.
82(2): 460-468, 1997.
Arterial vessel responses to sodium
nitroprusside (SNP) and acetylcholine (ACh) were measured in the
spinotrapezius muscle of sedentary (Sed) and treadmill-trained (Tr)
rats to determine whether these endothelium-dependent (ACh) and
-independent (SNP) mechanisms contribute to the
training-induced increase in functional vasodilation previously
observed. Control and maximal vessel diameters were similar between Sed
and Tr. After 8 wk of training, functional dilation (2-, 4-, and 8-Hz
contractions) was enhanced in all orders of vessels studied
[terminal feed artery (FA), largest arterioles (1A), and
intermediate-sized arterioles (2A)], but responses to SNP were
increased only in FA. Responses to ACh were not significantly increased
in any vessel order. After 16 wk of training, functional dilation had
regressed in Tr such that only the FA response to 4 Hz was
significantly elevated relative to Sed. However, the FA and 1A
responses to SNP were significantly greater in Tr than in Sed, as were
the 1A and 2A responses to ACh. These results show a dissociation of
functional dilation and SNP- or ACh-mediated responses, as well as
age-dependent interactions, a time-dependent progression, and vessel
order specificity in the adaptations to training.
nitric oxide; endothelium-derived relaxation factor; skeletal muscle blood flow; exercise hyperemia; microcirculation; muscle contractions
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