Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 82: 440-446, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 2, pp. 440-446, February 1997
EXERCISE AND MUSCLE

Respective oxidation of 13C-labeled lactate and glucose ingested simultaneously during exercise

F. Péronnet, Y. Burelle, D. Massicotte, C. Lavoie, and C. Hillaire-Marcel

Département d'Éducation Physique, Université de Montréal, Montréal, Province of Quebec, Canada H3C 3J7

Received 29 May 1996; accepted in final form 21 October 1996.

Péronnet, F., Y. Burelle, D. Massicotte, C. Lavoie, and C. Hillaire-Marcel. Respective oxidation of 13C-labeled lactate and glucose ingested simultaneously during exercise. J. Appl. Physiol. 82(2): 440-446, 1997.---The purpose of this experiment was to measure, by using 13C labeling, the oxidation rate of exogenous lactate (25 g, as Na+, K+, Ca2+, and Mg2+ salts) and glucose (75 g) ingested simultaneously (in 1,000 ml of water) during prolonged exercise (120 min, 65 ± 3% maximum oxygen uptake in 6 male subjects). The percentage of exogenous glucose and lactate oxidized were similar (48 ± 3 vs. 45 ± 5%, respectively). However, because of the small amount of oral lactate that could be tolerated without gastrointestinal discomfort, the amount of exogenous lactate oxidized was much smaller than that of exogenous glucose (11.1 ± 0.5 vs. 36.3 ± 1.3 g, respectively) and contributed to only 2.6 ± 0.4% of the energy yield (vs. 8.4 ± 1.9% for exogenous glucose). The cumulative amount of exogenous glucose and lactate oxidized was similar to that observed when 100 g of [13C]glucose were ingested (47.3 ± 1.8 vs. 50.9 ± 1.2 g, respectively). When [13C]glucose was ingested, changes in the plasma glucose 13C/12C ratio indicated that between 39 and 61% of plasma glucose derived from exogenous glucose. On the other hand, the plasma glucose 13C/12C ratio remained unchanged when [13C]lactate was ingested, suggesting no prior conversion into glucose before oxidation.

exogenous lactate; prolonged exercise; substrate oxidation; stable isotopes; insulin

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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