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Department of Physiology, The University of Arizona Health Sciences Center, Tucson, Arizona 85721-0093
Received 22 May 1996; accepted in final form 27 September 1996.
Mateika, J. H., and R. F. Fregosi. Long-term
facilitation of upper airway muscle activities in vagotomized and
vagally intact cats. J. Appl. Physiol.
82(2): 419-425, 1997.
The primary purpose of the present
investigation was to determine whether long-term facilitation (LTF) of
upper airway muscle activities occurs in vagotomized and vagally intact
cats. Tidal volume and diaphragm, genioglossus, and nasal dilator
muscle activities were recorded before, during, and after one carotid
sinus nerve was stimulated five times with 2-min trains of constant
current. Sixty minutes after stimulation, nasal dilator and
genioglossus muscle activities were significantly greater than control
in the vagotomized cats but not in the vagally intact cats. Tidal
volume recorded from the vagotomized and vagally intact cats was
significantly greater than control during the poststimulation period.
In contrast, diaphragm activities were not significantly elevated in
the poststimulation period in either group of animals. We conclude that
1) LTF of genioglossus and nasal
dilator muscle activities can be evoked in vagotomized cats;
2) vagal mechanisms inhibit LTF in
upper airway muscles; and 3) LTF can
be evoked in accessory inspiratory muscles because LTF of inspired
tidal volume was greater than LTF of diaphragm activity.
vagal inhibitory memory; carotid sinus nerve; nasal dilator muscle; genioglossus muscle
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