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J Appl Physiol 82: 377-381, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 2, pp. 377-381, February 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Prolongation in expiration evoked from ventrolateral pons of adult rats

Józef S. Jodkowski, Sharon K. Coles, and Thomas E. Dick

Departments of Medicine, Neuroscience, and Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-5000

Received 2 July 1996; accepted in final form 15 October 1996.

Jodkowski, Józef S., Sharon K. Coles, and Thomas E. Dick. Prolongation in expiration evoked from ventrolateral pons of adult rats. J. Appl. Physiol. 82(2): 377-381, 1997.---Activation of neurons in the ventrolateral (vl) pons was hypothesized to alter the breathing pattern because previous studies demonstrated apneusis after inhibiting neuronal activity with bilateral muscimol (10 mM) microinjections into the vl pons (17). The excitatory amino acid L-glutamate (10 mM) was microinjected (10-100 nl) into the vl pons in anesthetized, vagotomized, paralyzed, and ventilated adult rats (n = 8). In four of these animals, the target site was approached from the ventral surface of the pons to avoid penetrating the dorsolateral (dl) pons. The expiratory phase was prolonged transiently and concurrently with the microinjection. The location of the injection sites included the A5 area, was independent of the approach, and was distinct from the dl pons. These results complement our previous data and indicate that neurons located in the vl pons influence respiration specifically by prolonging expiration when activated and by delaying the inspiratory-to-expiratory phase transition when inhibited.

control of respiration; A5 area

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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