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O2
kinetics in old and young individuals
The Centre for Activity and Ageing, Faculty of Kinesiology, and Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
Received 28 February 1996; accepted in final form 22 August 1996.
Chilibeck, P. D., D. H. Paterson, D. A. Cunningham, A. W. Taylor, and E. G. Noble. Muscle capillarization,
O2 diffusion distance, and
O2 kinetics in old and
young individuals. J. Appl. Physiol.
82(1): 63-69, 1997.
The relationships between muscle capillarization, estimated O2
diffusion distance from capillary to mitochondria, and
O2 uptake
(O2) kinetics
were studied in 11 young (mean age, 25.9 yr) and 9 old (mean age, 66.0 yr) adults. O2
kinetics were determined by calculating the time constants (
) for
the phase 2 O2 adjustment to and
recovery from the average of 12 repeats of a 6-min, moderate-intensity
plantar flexion exercise. Muscle capillarization was determined from
cross sections of biopsy material taken from lateral gastrocnemius.
Young and old groups had similar
O2 kinetics
(O2-on = 44 vs. 48 s;
O2-off = 33 vs. 44 s, for young and old, respectively), muscle capillarization, and
estimated O2 diffusion distances.
Muscle capillarization, expressed as capillary density or average
number of capillary contacts per fiber/average fiber area, and the
estimates of diffusion distance were significantly correlated to
O2-off kinetics in the
young (r = 
0.68 to 0.83;
P < 0.05). We conclude that
1) capillarization and
O2 kinetics during exercise
of a muscle group accustomed to everyday activity (e.g., walking) are
well maintained in old individuals, and
2) in the young, recovery of O2 after exercise is
faster, with a greater capillary supply over a given muscle fiber area
or shorter O2 diffusion distances.
aging; plantar flexion; lateral gastrocnemius
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