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1 Departments of Medicine, Human Genetics, and Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106; and 2 Department of Physiology and Pharmacology, University of South Dakota, Vermillion, South Dakota 57069
Received 23 April 1996; accepted in final form 13 September 1996.
Strohl, Kingman P., Agnes J. Thomas, Pamela St. Jean, Evelyn
H. Schlenker, Richard J. Koletsky, and Nicholas J. Schork. Ventilation and metabolism among rat strains. J. Appl. Physiol. 82(1): 317-323, 1997.
We examined
ventilation and metabolism in four rat strains with variation in traits
for body weight and/or blood pressure regulation.
Sprague-Dawley [SD; 8 males (M), 8 females (F)], Brown
Norway (BN; 10 M, 11 F), and Zucker (Z; 11 M, 12 F) rats were compared
with Koletsky (K; 11 M, 11 F) rats. With the use of noninvasive
plethysmography, frequency, tidal volume, minute ventilation
(
E),
O2 consumption, and
CO2 production were derived at
rest during normoxia (room air) and during the 5th minute of exposure
to each of the following: hyperoxia (100% O2), hypoxia (10%
O2-balance
N2), and hypercapnia (7%
CO2-balance O2). Statistical methods probed
for strain and sex effects, with covariant analysis by body weight,
length, and body mass. During resting breathing, strain effects were
found with respect to both frequency (BN, Z > K, SD) and tidal volume
(SD > BN, Z) but not to E. Sex
influenced frequency (F > M) alone. Z rats had higher values for
O2 consumption,
CO2 production, and respiratory
quotient than the other three strains, with no independent effect by
sex. During hyperoxia, frequency was greater in BN and Z than in SD or
K rats; SD rats had a larger tidal volume than BN or Z rats; Z rats had
a greater E than K rats; and M had a
larger tidal volume than F. Strain differences persisted during
hypercapnia, with Z rats exhibiting the highest frequency and
E values. During hypoxic exposure,
strain effects were found to influence
E (SD > K, Z), frequency (BN > K), and tidal volume (SD > BN, K, Z). Body mass was only a
modest predictor of E during normoxia, of both E and tidal volume with
hypoxia, hypercapnia, or hyperoxia, and of frequency during
hypercapnia. We conclude that strain of rats, more than their body mass
or sex, has major and different influences on metabolism, the pattern
and level of ventilation during air breathing, and ventilation during
acute exposure to hypercapnia or hypoxia.
ventilatory control; genetics; rat strains
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