Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 82: 305-316, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stitt, J. T.
Right arrow Articles by Shimada, S. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stitt, J. T.
Right arrow Articles by Shimada, S. G.

Journal of Applied Physiology
Vol. 82, No. 1, pp. 305-316, January 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

Exhalation of gaseous nitric oxide by rats in response to endotoxin and its absorption by the lungs

John T. Stitt, Arthur B. Dubois, James S. Douglas, and Steven G. Shimada

The John B. Pierce Foundation Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519

Received 9 April 1996; accepted in final form 10 September 1996.

Stitt, John T., Arthur B. DuBois, James S. Douglas, and Steven G. Shimada. Exhalation of gaseous nitric oxide by rats in response to endotoxin and its absorption by the lungs. J. Appl. Physiol. 82(1): 305-316, 1997.---Rats injected with a lipopolysaccharide endotoxin produce detectable concentrations of nitric oxide gas (NO) in the expired air within 60 min. The concentration of NO reaches a plateau at 3 h. Production of the NO is dose dependent on lipopolysaccharide, and at a dose of 1 mg/kg iv, lipopolysaccharide alveolar concentrations of >260 parts per billion are observed. NO synthase inhibitors suppress this NO production in response to endotoxin. Experiments were conducted to ascertain the site of origin of this NO and to measure the capacity of the lungs to absorb NO from alveolar air. Results indicate that the endotoxin-induced NO originates from within the lungs themselves and that the lungs have the capacity to absorb >60% of NO that is presented to them. Lung tissues absorb ~44-47% of the NO load, blood carries away between 15 and 19%, while the remainder is exhaled in the expired air. It is proposed that the exhalation of NO might prove useful as an early biomarker for acute lung injury.

lung injury; neutrophils; endothelial cells

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 Innate ImmunityHome page
R. Kitz, M. A. Rose, A. Borgmann, R. Schubert, and S. Zielen
Systemic and bronchial inflammation following LPS inhalation in asthmatic and healthy subjects
Innate Immunity, December 1, 2006; 12(6): 367 - 374.
[Abstract] [PDF]

Home page
 Poult. Sci.Home page
O. T. Bowen, R. F. Wideman, N. B. Anthony, and G. F. Erf
Variation in the Pulmonary Hypertensive Responsiveness of Broilers to Lipopolysaccharide and Innate Variation in Nitric Oxide Production by Mononuclear Cells
Poult. Sci., August 1, 2006; 85(8): 1349 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
ATS Workshop Proceedings: Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate.
Proceedings of the ATS, January 1, 2006; 3(2): 131 - 145.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Deem, J.-U. Kim, B. N. Manjula, A. S. Acharya, M. E. Kerr, R. P. Patel, M. T. Gladwin, and E. R. Swenson
Effects of S-Nitrosation and Cross-Linking of Hemoglobin on Hypoxic Pulmonary Vasoconstriction in Isolated Rat Lungs
Circ. Res., October 4, 2002; 91(7): 626 - 632.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. T. Stitt and A. B. DuBois
The lung diffusing capacity for nitric oxide in rats is increased during endotoxemia
J Appl Physiol, March 1, 2001; 90(3): 1049 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
V. Strunk, K. Hahnenkamp, M. Schneuing, L. G. Fischer, and G. F. Rich
Selective iNOS Inhibition Prevents Hypotension in Septic Rats While Preserving Endothelium-Dependent Vasodilation
Anesth. Analg., March 1, 2001; 92(3): 681 - 687.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. A. Gollob, J. W. Mier, K. Veenstra, D. F. McDermott, D. Clancy, M. Clancy, and M. B. Atkins
Phase I Trial of Twice-Weekly Intravenous Interleukin 12 in Patients with Metastatic Renal Cell Cancer or Malignant Melanoma: Ability to Maintain IFN-{{gamma}} Induction Is Associated with Clinical Response
Clin. Cancer Res., May 1, 2000; 6(5): 1678 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. P. Pietropaoli, I. B. Perillo, A. Torres, P. T. Perkins, L. M. Frasier, M. J. Utell, M. W. Frampton, and R. W. Hyde
Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans
J Appl Physiol, October 1, 1999; 87(4): 1532 - 1542.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. W. Vandivier, A. Eidsath, S. M. Banks, H. L. Preas II, S. B. Leighton, P. J. Godin, A. F. Suffredini, and R. L. Danner
Down-Regulation of Nitric Oxide Production by Ibuprofen in Human Volunteers
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1398 - 1403.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online