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J Appl Physiol 82: 292-297, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 1, pp. 292-297, January 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Effect of Nomega -nitro-L-arginine on ventilatory response to hypercapnia in anesthetized cats

Luc Teppema, Aad Berkenbosch, and Cees Olievier

Department of Physiology, Leiden University, 2300 RC Leiden, The Netherlands

Received 6 May 1996; accepted in final form 3 September 1996.

Teppema, Luc, Aad Berkenbosch, and Cees Olievier Effect of Nomega -nitro-L-arginine on ventilatory response to hypercapnia in anesthetized cats. J. Appl. Physiol. 82(1): 292-297, 1997.---The effect of intravenous administration of 40 mg/kg Nomega -nitro-L-arginine (L-NNA), an inhibitor of the synthesis of nitric oxide (NO), on the ventilatory response to CO2 was studied in anesthetized cats. The ventilatory response to CO2 was assessed during normoxia by applying square-wave changes in end-tidal PCO2 of ~1 kPa. Each CO2 response was separated into a fast peripheral and slow central component characterized by a CO2 sensitivity (Sp and Sc, respectively), time constant, time delay, and an offset (apneic threshold). L-NNA reduced Sp, Sc, and the apneic threshold significantly by ~30%. However, the ratio Sp/Sc was not changed. It is argued that the reduction in Sp and Sc, Sp/Sc remaining constant, may be due to a potent inhibitory action of L-NNA on the brain stem respiratory-integrating centers and on the neuromechanical link between these centers and respiratory movements. It is concluded that NO plays an important role in the control of breathing.

nitric oxide; nitric oxide synthase inhibitor; control of breathing; carbon dioxide response

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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