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Cardiology Division, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6300
Received 22 May 1996; accepted in final form 17 September 1996.
Lang, Chim C., Don B. Chomsky, Glenn Rayos, T. K. Yeoh, and
John R. Wilson. Skeletal muscle mass and exercise performance in
stable ambulatory patients with heart failure. J. Appl. Physiol. 82(1): 257-261, 1997.
The purpose
of this study was to determine whether skeletal muscle atrophy limits
the maximal exercise capacity of stable ambulatory patients with heart
failure. Body composition and maximal exercise capacity were measured
in 100 stable ambulatory patients with heart failure. Body composition
was assessed by using dual-energy X-ray absorption. Peak exercise
oxygen consumption (
O2 peak) and the
anaerobic threshold were measured by using a Naughton treadmill
protocol and a Medical Graphics
CardioO2 System.
O2 peak averaged 13.4 ± 3.3 ml · min
1 · kg1
or 43 ± 12% of normal. Lean body mass averaged 52.9 ± 10.5 kg and leg lean mass 16.5 ± 3.6 kg. Leg lean mass correlated linearly with O2 peak
(r= 0.68, P < 0.01), suggesting that exercise
performance is influenced by skeletal muscle mass. However, lean body
mass was comparable to levels noted in 1,584 normal control subjects, suggesting no decrease in muscle mass. Leg muscle mass was comparable to levels noted in 34 normal control subjects, further supporting this
conclusion. These findings suggest that exercise intolerance in stable
ambulatory patients with heart failure is not due to skeletal muscle
atrophy.
body composition; lean body mass
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