Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol 82: 240-247, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 1, pp. 240-247, January 1997
CELLULAR ASPECTS OF LUNG FUNCTION

Effects of acute hyperoxic exposure on solute fluxes across the blood-gas barrier in rat lungs

Lu P. Zheng, Rui Sheng Du, and Barbara E. Goodman

Department of Physiology and Pharmacology, School of Medicine, University of South Dakota, Vermillion, South Dakota 57069

Received 19 January 1995; accepted in final form 28 August 1996.

Zheng, Lu P., Rui Sheng Du, and Barbara E. Goodman. Effects of acute hyperoxic exposure on solute fluxes across the blood-gas barrier in rat lungs. J. Appl. Physiol. 82(1): 240-247, 1997.---We investigated effects of acute hyperoxia on solute transport from air space to vascular space in isolated rat lungs. Air spaces were filled with Krebs-Ringer bicarbonate solution containing fluorescein isothiocyanate-labeled dextran (FD-20; mol wt 20,000) and either 22Na+ and [14C]sucrose, or D-[14C]glucose and L-[3H]glucose. Apparent permeability-surface area products for tracers over time (up to 120 min) were calculated for isolated perfused lungs from control rats (room air) and rats exposed to >95% O2 for 48 or 60 h immediately postexposure. After O2 exposures, mean fluxes for [14C]sucrose and FD-20 were significantly higher than in room-air control lungs. However, amiloride-sensitive Na+ and active D-glucose fluxes were unchanged after hyperoxic exposure. Therefore, it is unlikely that decreases in net solute transport in this lung-injury model contributed to pulmonary edema resulting from O2 toxicity. Increased net solute transport shown to help resolve pulmonary edema after acute hyperoxic exposure must therefore begin during the recovery period. In summary, our data show increases in passive solute fluxes but no changes in active solute fluxes immediately after acute hyperoxic lung injury.

amiloride; phloridzin; oxygen toxicity; pulmonary edema

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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