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1 Department of Respiratory Physiology,
Received 8 July 1994; accepted in final form 12 August 1996.
Cremona, George, Tim Higenbottam, Motoshi Takao, Edward A. Bower, and Leslie W. Hall. Nature and site of action of endogenous
nitric oxide in vasculature of isolated pig lungs. J. Appl. Physiol. 82(1): 23-31, 1997.
arterial and venous occlusion technique; double occlusion
technique; NG-nitro-L-arginine; hypoxic pulmonary vasoconstriction
The site of
action of endogenous and exogenous nitric oxide (NO) in isolated pig
lungs was investigated by using arterial, double, and venous occlusion,
which allowed precapillary, postcapillary, and venous segments to be
partitioned into arterial, precapillary, postcapillary, and venous
segments. NG-nitro-L-arginine
(L-NNA;
10
5 M) increased resistance
in the arterial (35 ± 6.6%, P = 0.003), precapillary (39.3 ± 5.1%,
P = 0.001), and venous (18.3 ± 4.8%, P = 0.01) segments,
respectively. Sodium nitroprusside
(105 M) and NO (80 parts/million) reversed the effects of
L-NNA. Total pulmonary vascular
resistance fell with increasing flow, due to a fall in precapillary
resistance and dynamic resistance, and was significantly
lower than mean total resistance.
L-NNA increased the resistances
but did not alter the pattern of the pressure-flow relationships. It is
concluded that, in isolated pig lungs, the effect of endogenous NO
seems to be dependent on flow in the arterial segment and independent
of flow in the precapillary segment, but variation of its release does
not appear to be fundamental to accommodation to changes in steady
flow.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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