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J Appl Physiol 82: 125-133, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 1, pp. 125-133, January 1997
EXERCISE AND MUSCLE

Gender-specific effects of dexamethasone treatment on rat diaphragm structure and function

D. J. Prezant1,2, M. L. Karwa1, B. Richner1, D. Maggiore1, E. I. Gentry1, and J. Cahill1

1 Department of Medicine, Pulmonary Division, and 2 Department of Physiology and Biophysics, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10467

Received 5 June 1995; accepted in final form 6 September 1996.

Prezant, D. J., M. L. Karwa, B. Richner, D. Maggiore, E. I. Gentry, and J. Cahill. Gender-specific effects of dexamethasone treatment on rat diaphragm structure and function. J. Appl. Physiol. 82(1): 125-133, 1997.---The effects of long-term dexamethasone treatment on diaphragm muscle were studied in female and male rats. Compared with pair-fed control animals, dexamethasone treatment did not significantly affect estrous cycling or peak serum estradiol levels; however, testosterone levels were significantly increased in females and decreased in males. Dexamethasone significantly reduced body and costal diaphragm weights, but to a lesser extent in females than in males. Reductions in diaphragm weight were proportional to reductions in body weight. In females and males, dexamethasone treatment significantly decreased diaphragm fiber (types I and II) cross-sectional area and the relative expression of myosin heavy chain isoform 2B. With the exception of type I fiber atrophy, these changes occurred to a lesser extent in females. Dexamethasone did not significantly affect specific forces. Dexamethasone significantly increased twitch one-half relaxation time and fatigue resistance indexes in males but not in females. In conclusion, the effects of long-term dexamethasone treatment were gender specific, with significantly fewer effects in females, and changes in serum testosterone levels were associated with these findings.

respiratory muscles; gender differences

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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