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J Appl Physiol 81: 2651-2657, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology
Vol. 81, No. 6, pp. 2651-2657, December 1996
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Arousal pattern following central and obstructive breathing abnormalities in infants and children

Frances McNamara, Faiq G. Issa, and Colin E. Sullivan

National Sudden Infant Death Syndrome Council David Read Paediatric Sleep Disorders Unit, Royal Alexandra Hospital for Children, Camperdown 2050; and Department of Medicine, University of Sydney, Sydney, New South Wales 2006, Australia

Received 21 February 1996; accepted in final form 1 October 1996.

McNamara, Frances, Faiq G. Issa, and Colin E. Sullivan. Arousal pattern following central and obstructive breathing abnormalities in infants and children. J. Appl. Physiol. 81(6): 2651-2657, 1996.---We analyzed the polysomnographic records of 15 children and 20 infants with obstructive sleep apnea (OSA) to examine the interaction between central and obstructive breathing abnormalities and arousal from sleep. Each patient was matched for age with an infant or child who had no OSA. We found that the majority of respiratory events in infants and children was not terminated with arousal. In children, arousals terminated 39.3 ± 7.2% of respiratory events during quiet sleep and 37.8 ± 7.2% of events during active (rapid-eye-movement) sleep. In infants, arousals terminated 7.9 ± 1.0% of events during quiet sleep and 7.9 ± 1.2% of events during active sleep. In both infants and children, however, respiratory-related arousals occurred more frequently after obstructive apneas and hypopneas than after central events. Spontaneous arousals occurred in all patients with OSA during quiet and active sleep. The frequency of spontaneous arousals was not different between children with OSA and their matched controls. During active sleep, however, infants with OSA had significantly fewer spontaneous arousals than did control infants. We conclude that arousal is not an important mechanism in the termination of respiratory events in infants and children and that electroencephalographic criteria are not essential to determine the clinical severity of OSA in the pediatric population.

obstructive sleep apnea; central sleep apnea; arousal

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




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