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Departments of Pediatrics and Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46223; and School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907
Received 17 April 1996; accepted in final form 6 August 1996.
Shen, X., V. Bhargava, G. R. Wodicka, C. M. Doerschuk, S. J. Gunst, and R. S. Tepper. Greater airway narrowing in immature than
in mature rabbits during methacholine challenge. J. Appl. Physiol. 81(6): 2637-2643, 1996.
It has
been demonstrated that methacholine (MCh) challenge produces a greater
increase in lung resistance in immature than in mature rabbits (R. S. Tepper, X. Shen, E. Bakan, and S. J. Gunst.
J. Appl. Physiol. 79: 1190-1198, 1995). To determine whether this maturational difference in the response to MCh was primarily related to changes in airway resistance (Raw) or changes in tissue resistance, we assessed airway narrowing in
1-, 2-, and 6-mo-old rabbits during intravenous MCh challenge (0.01-5.0 mg/kg). Airway narrowing was determined from
measurements of Raw in vivo and from morphometric measurements on lung
sections obtained after rapidly freezing the lung after the MCh
challenge. The fold increase in Raw was significantly greater for 1- and 2-mo-old animals than for 6-mo-old animals. Similarly, the degree of airway narrowing assessed morphometrically was significantly greater
for 1- and 2-mo-old animals than for 6-mo-old animals. The fold
increase in Raw was highly correlated with the degree of airway
narrowing assessed morphometrically
(r2 = 0.82, P < 0.001). We conclude that the
maturational difference in the effect of MCh on lung resistance is
primarily caused by greater airway narrowing in the immature rabbits.
airway reactivity; maturation; airway morphometry
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